asiminacin

Base Information

Chemical Name:asiminacin
CAS No.:156199-51-8
Molecular Formula:C₃₇H₆₆O₇
Molecular Weight:622.927
Hs Code.:
Mol file:156199-51-8.mol

Synonyms:2(5H)-Furanone,3-[13-[5'-(1,5-dihydroxyundecyl)octahydro[2,2'-bifuran]-5-yl]-13-hydroxytridecyl]-5-methyl-,[2R-[2a[2'R*,5'R*(1R*,5S*)],5b[R*(S*)]]]-; Asiminacin;Squamocin D

Suppliers and Price of asiminacin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of asiminacin

Chemical Property:

Vapor Pressure:3.8E-27mmHg at 25°C
Boiling Point:766.8°C at 760 mmHg
Flash Point:228.1°C
PSA：105.45000
Density:1.054g/cm³
LogP:7.85790

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of asiminacin

There total 19 articles about asiminacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 286853-96-1
(5S,13'R,2''R,5''R,2'''R,5'''R,1''''R,5''''S)-3-[13'-(5''-(5'''-(1'''',5''''-bis(tert-butyldimethylsilyloxy)undec-1''''-yl)tetrahydrofuran-2'''-yl)tetrahydrofuran-2''-yl)-13'-(tert-butyldimethylsilyloxy)tridec-1-yl]-5-methylfuran-2(5H)-one

: 156199-51-8
asiminacin

Guidance literature:: With HF (5percent in MeCN); In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1002/(SICI)1099-0690(200005)2000:10<1889::AID-EJOC1889>3.0.CO;2-R

Reference yield:

: 111-71-7
heptanal

: 156199-51-8
asiminacin

Guidance literature:: Multi-step reaction with 16 steps

1.1: (R)-BINOL; mol sieves 4 Angstroem; Ti(OiPr)4 / CH₂Cl₂ / 1 h / 20 °C

1.2: 68 percent / CH₂Cl₂ / 120 h / -78 - -25 °C

2.1: 98 percent / imidazole / CH₂Cl₂; toluene / 20 °C

3.1: tetrahydrofuran / 18 h / 20 °C

4.1: NaOH; 30percent H₂O₂ / tetrahydrofuran / 5 h

5.1: 82 percent / pyridine / CH₂Cl₂ / 0 °C

6.1: 93 percent / LiBr / tetrahydrofuran / 32 h / 35 °C

7.1: Mg; BrCH₂CH₂Br / diethyl ether / 1 h / 35 °C

7.2: diethyl ether

8.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 0.75 h / 20 °C

9.1: 99 percent / hydrogen / 10percent Pd/c / propan-2-ol / 3 h / 20 °C

10.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -50 - 0 °C

11.1: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

12.1: LDA; LiCl / tetrahydrofuran / 0.5 h / 20 °C

12.2: tetrahydrofuran / 20 °C

13.1: pivaloyl chloride; Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

14.1: KHMDS / tetrahydrofuran / 0 - 20 °C

14.2: tetrahydrofuran / 1 h / 0 °C

15.1: monoperoxyphthalic acid (85percent) / tetrahydrofuran; methanol / 0.33 h / 20 °C

16.1: 79 percent / HF (5percent in MeCN) / tetrahydrofuran / 2 h / 20 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; titanium(IV) isopropylate; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 4 A molecular sieve; hydrogen; (R)-1,1'-Bi-2-naphthol; pivaloyl chloride; potassium hexamethylsilazane; magnesium; dimethyl sulfoxide; ethylene dibromide; triethylamine; lithium chloride; lithium bromide; lithium diisopropyl amide; 10percent Pd/c; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; isopropyl alcohol; toluene; tert-butyl alcohol; 1.1: Addition / 1.2: Substitution / 2.1: silylation / 3.1: Addition / 4.1: Oxidation / 5.1: Tosylation / 6.1: Bromination / 7.1: Metallation / 7.2: Grignard reaction / 8.1: silylation / 9.1: Hydrogenolysis / 10.1: Oxidation / 11.1: Oxidation / 12.1: Metallation / 12.2: Alkylation / 13.1: Cyclization / 14.1: Metallation / 14.2: Substitution / 15.1: Elimination / 16.1: desilylation;
DOI:10.1002/(SICI)1099-0690(200005)2000:10<1889::AID-EJOC1889>3.0.CO;2-R

Reference yield:

: 123464-22-2
(S)-(-)-1-decen-4-ol

: 156199-51-8
asiminacin

Guidance literature:: Multi-step reaction with 15 steps

1.1: 98 percent / imidazole / CH₂Cl₂; toluene / 20 °C

2.1: tetrahydrofuran / 18 h / 20 °C

3.1: NaOH; 30percent H₂O₂ / tetrahydrofuran / 5 h

4.1: 82 percent / pyridine / CH₂Cl₂ / 0 °C

5.1: 93 percent / LiBr / tetrahydrofuran / 32 h / 35 °C

6.1: Mg; BrCH₂CH₂Br / diethyl ether / 1 h / 35 °C

6.2: diethyl ether

7.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 0.75 h / 20 °C

8.1: 99 percent / hydrogen / 10percent Pd/c / propan-2-ol / 3 h / 20 °C

9.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -50 - 0 °C

10.1: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

11.1: LDA; LiCl / tetrahydrofuran / 0.5 h / 20 °C

11.2: tetrahydrofuran / 20 °C

12.1: pivaloyl chloride; Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

13.1: KHMDS / tetrahydrofuran / 0 - 20 °C

13.2: tetrahydrofuran / 1 h / 0 °C

14.1: monoperoxyphthalic acid (85percent) / tetrahydrofuran; methanol / 0.33 h / 20 °C

15.1: 79 percent / HF (5percent in MeCN) / tetrahydrofuran / 2 h / 20 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; magnesium; dimethyl sulfoxide; ethylene dibromide; triethylamine; lithium chloride; lithium bromide; lithium diisopropyl amide; 10percent Pd/c; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; isopropyl alcohol; toluene; tert-butyl alcohol; 1.1: silylation / 2.1: Addition / 3.1: Oxidation / 4.1: Tosylation / 5.1: Bromination / 6.1: Metallation / 6.2: Grignard reaction / 7.1: silylation / 8.1: Hydrogenolysis / 9.1: Oxidation / 10.1: Oxidation / 11.1: Metallation / 11.2: Alkylation / 12.1: Cyclization / 13.1: Metallation / 13.2: Substitution / 14.1: Elimination / 15.1: desilylation;
DOI:10.1002/(SICI)1099-0690(200005)2000:10<1889::AID-EJOC1889>3.0.CO;2-R