1-(alpha-(Hydroxymethyl)phenethyl)-3-phenylurea

Base Information

• Chemical Name: 1-(alpha-(Hydroxymethyl)phenethyl)-3-phenylurea
• CAS No.: 19071-54-6
• Molecular Formula: C16H18N2O2
• Molecular Weight: 0
• Mol file: 19071-54-6.mol

Synonyms:1-(1-hydroxy-3-phenyl-propan-2-yl)-3-phenyl-urea;Urea, 1-(alpha-(hydroxymethyl)phenethyl)-3-phenyl-;

Chemical Property of 1-(alpha-(Hydroxymethyl)phenethyl)-3-phenylurea

Chemical Property:

• Vapor Pressure: 5.41E-09mmHg at 25°C
• Refractive Index: 1.63
• Boiling Point: 452.9°Cat760mmHg
• Flash Point: 227.7°C
• PSA: 64.85000
• Density: 1.212g/cm³
• LogP: 2.81620

Purity/Quality:

99% ^*data from raw suppliers

1-(ALPHA-(HYDROXYMETHYL)PHENETHYL)-3-PHENYLUREA 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(alpha-(Hydroxymethyl)phenethyl)-3-phenylurea

There total 7 articles about 1-(alpha-(Hydroxymethyl)phenethyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-Phenyl-2-(3-phenyl-ureido)-propionic acid methyl ester → C16H18N2O2 (19071-54-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 - 20 ℃; for 5h;

DOI:10.3184/174751915X14307583240337

Reference yield:

(S)-3-phenyl-2-(3-phenyl-ureido)-propionic acid methyl ester (138088-28-5,138088-48-9,23631-66-5) → 1-((S)-1-Hydroxymethyl-2-phenyl-ethyl)-3-phenyl-urea (223600-53-1,19071-54-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 5h;

DOI:10.1081/SCC-120022481

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → 1-((S)-1-Hydroxymethyl-2-phenyl-ethyl)-3-phenyl-urea (223600-53-1,19071-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DIEA / CH₂Cl₂ / 5 h / 20 °C

2: NaBH₄ / tetrahydrofuran; H₂O / 5 h / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1081/SCC-120022481

upstream raw materials:

L-Phenylalaninol

phenyl isocyanate

(S)-3-phenyl-2-(3-phenyl-ureido)-propionic acid methyl ester

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Refernces

• 1、 Zeng, Bitao,Zhao, Zhigang,Zhou, Lijun,Li, Qinghan. "Synthesis of novel chiral cholic acid-based molecular tweezers containing unsymmetrically disubstituted urea units using microwave irradiation". scheme or table. p. 206 - 209. Retrieved 2012/09/08.
• 2、 Mu, Qi Ming,Xue, Cui Hua,Zhang, Qing Hua,Chen, Shu Hua. "The synthesis of novel chiral cholic acid-based molecular clefts containing unsymmetrically disubstituted urea unit". . p. 3055 - 3061. Retrieved 2007/10/03.