6,9-Etheno-4,19-(iminomethano)-11,15:20,24-dimetheno-1H-10,2,18-benzoxadiazacyclohexacosine-1-carboxylicacid, 13-[4-[(2R)-2-carboxy-2-[[(phenylmethoxy)carbonyl]amino]ethyl]-2-chlorophenoxy]-8-chloro-16-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3,4,5,16,17,18,19-octahydro-5,12,23,25,27-pentahydroxy-3,17,30-trioxo-,1-methyl ester, (1S,4S,5R,16R,19R)- (9CI)

Base Information

• Chemical Name: 6,9-Etheno-4,19-(iminomethano)-11,15:20,24-dimetheno-1H-10,2,18-benzoxadiazacyclohexacosine-1-carboxylicacid, 13-[4-[(2R)-2-carboxy-2-[[(phenylmethoxy)carbonyl]amino]ethyl]-2-chlorophenoxy]-8-chloro-16-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3,4,5,16,17,18,19-octahydro-5,12,23,25,27-pentahydroxy-3,17,30-trioxo-,1-methyl ester, (1S,4S,5R,16R,19R)- (9CI)
• CAS No.: 164515-56-4
• Molecular Formula: C56H51 Cl2 N5 O18
• Molecular Weight: 1152.95
• Mol file: 164515-56-4.mol

Synonyms:6,9-Etheno-4,19-(iminomethano)-11,15:20,24-dimetheno-1H-10,2,18-benzoxadiazacyclohexacosine-1-carboxylicacid,13-[4-[2-carboxy-2-[[(phenylmethoxy)carbonyl]amino]ethyl]-2-chlorophenoxy]-8-chloro-16-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3,4,5,16,17,18,19-octahydro-5,12,23,25,27-pentahydroxy-3,17,30-trioxo-,1-methyl ester, [1S-[1R*,4R*,5S*,13(S*),16S*,19S*]]-

Chemical Property of 6,9-Etheno-4,19-(iminomethano)-11,15:20,24-dimetheno-1H-10,2,18-benzoxadiazacyclohexacosine-1-carboxylicacid, 13-[4-[(2R)-2-carboxy-2-[[(phenylmethoxy)carbonyl]amino]ethyl]-2-chlorophenoxy]-8-chloro-16-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3,4,5,16,17,18,19-octahydro-5,12,23,25,27-pentahydroxy-3,17,30-trioxo-,1-methyl ester, (1S,4S,5R,16R,19R)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,9-Etheno-4,19-(iminomethano)-11,15:20,24-dimetheno-1H-10,2,18-benzoxadiazacyclohexacosine-1-carboxylicacid, 13-[4-[(2R)-2-carboxy-2-[[(phenylmethoxy)carbonyl]amino]ethyl]-2-chlorophenoxy]-8-chloro-16-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3,4,5,16,17,18,19-octahydro-5,12,23,25,27-pentahydroxy-3,17,30-trioxo-,1-methyl ester, (1S,4S,5R,16R,19R)- (9CI)

There total 5 articles about 6,9-Etheno-4,19-(iminomethano)-11,15:20,24-dimetheno-1H-10,2,18-benzoxadiazacyclohexacosine-1-carboxylicacid, 13-[4-[(2R)-2-carboxy-2-[[(phenylmethoxy)carbonyl]amino]ethyl]-2-chlorophenoxy]-8-chloro-16-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3,4,5,16,17,18,19-octahydro-5,12,23,25,27-pentahydroxy-3,17,30-trioxo-,1-methyl ester, (1S,4S,5R,16R,19R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl chloroformate (501-53-1,94274-21-2) + C48H45Cl2N5O16 (164515-55-3) → C56H51Cl2N5O18 (164515-56-4)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; for 0.0833333h; Ambient temperature;

DOI:10.1021/jo9506746

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → C56H51Cl2N5O18 (164515-56-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.9 g / NaHCO₃ / dioxane; H₂O / 7 h / -5 °C

2: 50 percent / CF₃CO₂H

3: 100 percent / NaHCO₃ / dioxane; H₂O / 0.08 h / Ambient temperature

With sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane; water;

DOI:10.1021/jo9506746

Reference yield:

C59H49Cl2N7O19 → C56H51Cl2N5O18 (164515-56-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) PhNCS, 2.) CF₃CO₂H / 1.) Py, H₂O, room temperature, 2.) room temperature

2: 0.9 g / NaHCO₃ / dioxane; H₂O / 7 h / -5 °C

3: 50 percent / CF₃CO₂H

4: 100 percent / NaHCO₃ / dioxane; H₂O / 0.08 h / Ambient temperature

With sodium hydrogencarbonate; phenyl isothiocyanate; trifluoroacetic acid; In 1,4-dioxane; water;

DOI:10.1021/jo9506746

upstream raw materials:

benzyl chloroformate

C₄₈H₄₅Cl₂N₅O₁₆

di-tert-butyl dicarbonate

C₄₃H₃₇Cl₂N₅O₁₄

Refernces