5-Methyl-1H-indazole-3-carboxylic acid

Base Information

• Chemical Name: 5-Methyl-1H-indazole-3-carboxylic acid
• CAS No.: 1201-24-7
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Hs Code.: 2933990090
• Mol file: 1201-24-7.mol

Synonyms:5-Methylindazole-3-carboxylic acid;

Chemical Property of 5-Methyl-1H-indazole-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.23E-08mmHg at 25°C
• Melting Point: 343 °C
• Refractive Index: 1.709
• Boiling Point: 443.27 °C at 760 mmHg
• PKA: 3.11±0.30(Predicted)
• Flash Point: 221.882 °C
• PSA: 65.98000
• Density: 1.422 g/cm³
• LogP: 1.56950
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Methyl-1h-indazole-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 5-Methyl-1H-indazole-3-carboxylic acid is a chemical compound with versatile applications in different fields. In the pharmaceutical industry, it serves as a key intermediate in the synthesis of various drugs and pharmaceutical compounds. Its unique chemical structure makes it valuable for the development of medications targeting a range of medical conditions, including neurological and inflammatory disorders. In the field of organic chemistry, this compound can play a pivotal role as a building block for the creation of complex organic molecules, facilitating the synthesis of a wide array of organic compounds. The specific role and significance of 5-Methyl-1H-indazole-3-carboxylic acid can vary depending on the particular research or industrial requirements within each field, underscoring its potential versatility and importance in diverse scientific and industrial applications.

Technology Process of 5-Methyl-1H-indazole-3-carboxylic acid

There total 7 articles about 5-Methyl-1H-indazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-methyl-indole-2,3-dione (608-05-9) → 5-methyl-1H-indazole-3-carboxylic acid (1201-24-7)

Guidance literature:

5-methyl-indole-2,3-dione; With sodium hydroxide; sulfuric acid; sodium nitrite; In water; at 0 ℃;

With hydrogenchloride; tin(ll) chloride; In diethyl ether; water; at 0 ℃;

DOI:10.1080/00397910500214318

Reference yield: 84.0%

5-methyl-indole-2,3-dione (608-05-9) → 5-Methyl-3-indazolone (7364-26-3) + 5-methyl-1H-indazole-3-carboxylic acid (1201-24-7)

Guidance literature:

5-methyl-indole-2,3-dione; With sodium hydroxide; sulfuric acid; sodium nitrite; In water; at 0 ℃;

With sodium sulfite; In diethyl ether; water; at 20 ℃; for 12h;

DOI:10.1080/00397910500214318

Reference yield:

1-benzylideneamino-5-methyl-indole-2,3-dione (10501-70-9) → 5-methyl-1H-indazole-3-carboxylic acid (1201-24-7)

Guidance literature:

With hydrogenchloride; water; acetic acid; at 90 ℃; for 2h;

upstream raw materials:

5-methyl-indole-2,3-dione

1-benzylideneamino-5-methyl-indole-2,3-dione

benzaldehyde

benzaldehyde p-tolylhydrazone

Downstream raw materials:

5-methyl-1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid ethyl ester

3-ethoxycarbonyl-5-methyl-1H-indazole

5-methyl-1H-indazole-3-carboxylic acid (4-fluorophenyl)amide

5-methyl-1H-indazole

Refernces

• 1、 Crocetti, Letizia,Schepetkin, Igor A.,Cilibrizzi, Agostino,Graziano, Alessia,Vergelli, Claudia,Giomi, Donatella,Khlebnikov, Andrei I.,Quinn, Mark T.,Giovannoni, Maria Paola. "Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase". . p. 6259 - 6272. Retrieved 2013/09/02.
• 2、 -. "1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS CYCLIN DEPENDENT KINASES (CDK) INHIBITORS". Page 93. . Retrieved 2010/02/06.