4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester
• CAS No.: 158146-85-1
• Molecular Formula: C25H26 N4 O6
• Molecular Weight: 478.505
• Mol file: 158146-85-1.mol

Synonyms:TAK 603

Chemical Property of 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 2.59E-16mmHg at 25°C
• Boiling Point: 640.7°C at 760 mmHg
• Flash Point: 341.3°C
• Density: 1.29g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester

There total 14 articles about 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-amino-1-[4-(3,4-dimethoxyphenyl)-3-ethoxy-carbonyl-6,7-dimethoxyquinolin-2-ylmethyl]-4H-1,2,4-triazolium bromide → 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester (158146-85-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium nitrite; In water;

Reference yield: 92.8%

4-amino-1-[4-(3,4-dimethoxyphenyl)-3-ethoxy-carbonyl-6,7-dimethoxyquinolin-2-ylmethyl]-4H-1,2,4-triazolium bromide + 5N-NaOH → 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester (158146-85-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water;

Reference yield: 53.0%

1,2,4-Triazole (288-88-0) + 2-chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinoline-3-carboxylic acid ethyl ester (153394-50-4) → 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester (158146-85-1)

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

1,2,4-Triazole

2-chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinoline-3-carboxylic acid ethyl ester

2-acetylamino-3',4,4'-5-tetramethoxybenzophenone

ethyl (2-chloroaceto)acetate

Refernces

• 1、 -. "Pharmaceutical composition containing quinoline or quinazoline derivatives". . . Retrieved 2008/06/13.
• 2、 -. "Processes for production of quinoline or quinazoline derivatives and intermediates therefor". . . Retrieved 2008/06/13.