Amifloxacin N-oxide

Base Information

Chemical Name:Amifloxacin N-oxide
CAS No.:88569-53-3
Molecular Formula:C₁₆H₁₉FN₄O₄
Molecular Weight:350.35
Hs Code.:
UNII:8URY13MH64
ChEMBL ID:CHEMBL269231
DSSTox Substance ID:DTXSID201111525
Nikkaji Number:J348.024K
Wikidata:Q27271044
Mol file:88569-53-3.mol

Synonyms:amifloxacin N-oxide

Suppliers and Price of Amifloxacin N-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Amifloxacin N-oxide

Chemical Property:

Vapor Pressure:5.17E-14mmHg at 25°C
Boiling Point:573.9°C at 760 mmHg
Flash Point:300.9°C
PSA：91.97000
Density:1.47g/cm³
LogP:1.16400
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:350.13903326
Heavy Atom Count:25
Complexity:591

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNN1C=C(C(=O)C2=CC(=C(C=C21)N3CC[N+](CC3)(C)[O-])F)C(=O)O

Technology Process of Amifloxacin N-oxide

There total 7 articles about Amifloxacin N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 86393-37-5
amifloxacin

: 88569-53-3
6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 4'-oxide

Guidance literature:: With sodium hydroxide; palladium on activated charcoal; dihydrogen peroxide; 1.) 45 deg C, 20 h, 2.) 25 deg C, 1 h;
DOI:10.1021/jm00375a003

Reference yield:

: 109-01-3
1-methyl-piperazine

: 88569-53-3
6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 4'-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / pyridine / 15 h / Heating

2: 82 percent / 1.) 0.1N NaOH, 30percent H₂O₂, 2.) 10percent Pd/C / 1.) 45 deg C, 20 h, 2.) 25 deg C, 1 h

With sodium hydroxide; palladium on activated charcoal; dihydrogen peroxide; In pyridine;
DOI:10.1021/jm00375a003

Reference yield:

: 75073-15-3
ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate

: 88569-53-3
6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 4'-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / K₂CO₃, O-(2,4-dinitrophenyl)hydroxylamine / dimethylformamide / 3 h / Ambient temperature

2: 1.) acetic anhydride / 1.) 0-50 deg C, 30 min, 2.) 25 deg C, 3.5 d

3: 90 percent / K₂CO₃ / dimethylformamide / 1.5 h / Ambient temperature

4: 91 percent / NaOH / H₂O / 2 h / Heating

5: 65 percent / pyridine / 15 h / Heating

6: 82 percent / 1.) 0.1N NaOH, 30percent H₂O₂, 2.) 10percent Pd/C / 1.) 45 deg C, 20 h, 2.) 25 deg C, 1 h

With sodium hydroxide; palladium on activated charcoal; dihydrogen peroxide; acetic anhydride; potassium carbonate; O-(2,4-dinitrophenyl)hydroxylamine; In pyridine; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00375a003