Chemical Property of Cucurbitacin IIb
Chemical Property:
- Vapor Pressure:1.01E-20mmHg at 25°C
- Melting Point:158-159oC
- Boiling Point:668.4oC at 760 mmHg
- PKA:12.86±0.29(Predicted)
- Flash Point:372oC
- PSA：135.29000
- Density:1.22g/cm3
- LogP:2.94430
- Storage Temp.:2-8°C
- XLogP3:2
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:5
- Exact Mass:520.34000387
- Heavy Atom Count:37
- Complexity:1020
- Purity/Quality:
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99%, *data from raw suppliers
Cucurbitacin IIb *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1(C(C(CC2C1=CCC3C2(C(=O)CC4(C3(CC(C4C(C)(C(=O)CCC(C)(C)O)O)O)C)C)C)O)O)C
- Isomeric SMILES:C[C@@]12C[C@H]([C@@H]([C@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H]([C@H](C4(C)C)O)O)C)C)[C@](C)(C(=O)CCC(C)(C)O)O)O
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Description
Cucurbitacin IIa and cucurbitacin IIb are the characteristic chemical constituents of
the hemsleya. Hemsleyadinum are extracted from the Cucurbitaceae,
Chrysanthemum, and Hemsleya, which have the function of clearing heat and
removing toxicity and antisepsis and anti-inflammation. There are 31 species of
Hemsleya in the world, most of which are distributed in China’s Yunnan, Guizhou,
and Sichuan provinces, besides the 2 species distributed in India and Vietnam. The
main species are H. emiensis, H. pengxianensis, H. amabilis, H. dolichocarpa, H.
graciliflora, and H. gigantha . Hemsleya plants are commonly used as Chinese
herbal medicines.
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Physical properties
Appearance: rhombohedral or flaky crystals, Solubility: soluble in methanol, ethanol, and acetone, slightly soluble in chloroform, insoluble in water.
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Indications
Its dosage forms and indications are available at the Pharmacopoeia of the People’s
Republic of China (1977).
The current clinical use of hemsleyadinum includes tablets and capsules, which
are suitable for bacillary dysentery, enteritis, bronchitis, and acute tonsillitis.
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Clinical Use
At present, hemsleyadinum mainly are used as antibacterial and anti-inflammatory
drugs, suitable for treatment of upper respiratory tract infection, acute tonsillitis,
mumps, pharyngitis, acute and chronic bronchitis, pneumonia etc. Generally speaking,
hemsleyadinum and its preparations have less side effects, such as diarrhea, abdominal pain, and other gastrointestinal reactions.
