Fosaprepitant

Base Information

• Chemical Name: Fosaprepitant
• CAS No.: 172673-20-0
• Molecular Formula: C23H22F7N4O6P
• Molecular Weight: 614.413
• Mol file: 172673-20-0.mol

Synonyms:Phosphonicacid,[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-(9CI);Phosphonic acid,[3-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-,[2R-[2a(R*),3a]]-;Phosphonic acid,P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-;L 758298;

Chemical Property of Fosaprepitant

Chemical Property:

• Vapor Pressure: 1.03E-14mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 588.9 °C at 760 mmHg
• PKA: 2.45±0.20(Predicted)
• Flash Point: 310 °C
• PSA: 139.72000
• Density: 1.65 g/cm³
• LogP: 4.30420
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO, Methanol

Purity/Quality:

Fosaprepitant >99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug. An antiemetic drug, a Aprepitant prodrug. Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
• Clinical Use: #N/A
• Drug interactions: Potentially hazardous interactions with other drugs Antidepressants: avoid with St John’s wort. Antipsychotics: avoid with pimozide. Cytotoxics: possibly increases bosutinib concentration - avoid or reduce bosutinib dose. Oestrogens and progestogens: may cause contraceptive failure.