10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium

Base Information

Chemical Name:10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium
CAS No.:19716-72-4
Molecular Formula:C20H18NO4+
Molecular Weight:336.3607
Hs Code.:

Synonyms:

Suppliers and Price of 10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium

Chemical Property:

Purity/Quality:: ≥98% （HPLC） ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium

There total 9 articles about 10,11-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10,11-dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline

: 19716-72-4
φ-Berberin

Guidance literature:: With iodine; potassium acetate; In ethanol; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201601245

Reference yield:

: C₂₁H₂₀BrNO₄

: 19716-72-4
φ-Berberin

Guidance literature:: Multi-step reaction with 5 steps

1: sodium formate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere

2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve

3: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere

4: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere

5: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere

With aluminum (III) chloride; Wilkinson's catalyst; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; diphenyl phosphoryl azide; iodine; sodium formate; potassium acetate; 4-methylmorpholine N-oxide; In diethyl ether; ethanol; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; acetonitrile; 3: |Wilkinson Decarbonylation;
DOI:10.1002/chem.201601245

Reference yield:

: 94143-83-6
5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

: 19716-72-4
φ-Berberin

Guidance literature:: Multi-step reaction with 7 steps

1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve

2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

3: sodium formate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere

4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve

5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere

6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere

7: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere

With aluminum (III) chloride; copper(l) iodide; Wilkinson's catalyst; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; diphenyl phosphoryl azide; iodine; sodium formate; potassium acetate; potassium carbonate; 4-methylmorpholine N-oxide; benzoic acid; In methanol; diethyl ether; ethanol; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile; 5: |Wilkinson Decarbonylation;
DOI:10.1002/chem.201601245