Technology Process of 1-fluoro-9H-fluorene
There total 7 articles about 1-fluoro-9H-fluorene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[bis(acetoxy)iodo]benzene; (R)-10-camphorsulfonic acid; tetrahydrothiophene gold(III) bromide;
In
methanol; chloroform;
at 27 ℃;
for 16h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/jacv6b10018
- Guidance literature:
-
With
N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride; palladium diacetate; potassium carbonate;
In
1-methyl-pyrrolidin-2-one;
at 130 ℃;
for 12h;
Inert atmosphere;
Sealed tube;
DOI:10.1002/adsc.201000651
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere; Schlenk technique
1.2: 2 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
2.1: trifluoroacetic acid / dichloromethane / 0.03 h / 0 °C / Inert atmosphere; Schlenk technique
2.2: 0 - 20 °C / Inert atmosphere; Schlenk technique
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique
3.2: -78 - 20 °C / Inert atmosphere; Schlenk technique
4.1: tetrahydrothiophene gold(III) bromide; [bis(acetoxy)iodo]benzene; (R)-10-camphorsulfonic acid / methanol; chloroform / 16 h / 27 °C / Schlenk technique; Inert atmosphere
With
n-butyllithium; [bis(acetoxy)iodo]benzene; (R)-10-camphorsulfonic acid; tetrahydrothiophene gold(III) bromide; diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; hexane; dichloromethane; chloroform;
DOI:10.1021/jacv6b10018
