1-(2-((4-Fluorophenyl)phenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine

Base Information

Chemical Name:1-(2-((4-Fluorophenyl)phenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine
CAS No.:76778-24-0
Molecular Formula:C₂₈H₃₃FN₂O
Molecular Weight:432.581
Hs Code.:
UNII:VV7LD54HCX
ChEMBL ID:CHEMBL41606
Nikkaji Number:J248.080H
Wikipedia:GBR-13119
Mol file:76778-24-0.mol

Synonyms:1-(2-(diphenylmethoxy)ethyl)-4-(3-(4-fluorophenyl)propyl)piperazine;GBR 13119;GBR-13119

Suppliers and Price of 1-(2-((4-Fluorophenyl)phenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-(2-((4-Fluorophenyl)phenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine

Chemical Property:

PSA：15.71000
LogP:5.05790
XLogP3:5.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:432.25769184
Heavy Atom Count:32
Complexity:490

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=C(C=C4)F

Technology Process of 1-(2-((4-Fluorophenyl)phenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine

There total 5 articles about 1-(2-((4-Fluorophenyl)phenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(3-phenylpropyl)-piperazine dihydrochloride

: C₁₅H₁₄FIO

: 76778-24-0
1-[2-[(4-fluorophenyl)(phenyl)methoxy]ethyl]-4-(3-phenylprypyl)piperazine

Guidance literature:: With sodium carbonate; In water; butanone; at 75 - 80 ℃; for 22.5h; Large scale;
DOI:10.1021/op020211j

Reference yield:

: 345-83-5
4-fluorobenzophenone

: 76778-24-0
1-[2-[(4-fluorophenyl)(phenyl)methoxy]ethyl]-4-(3-phenylprypyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / isopropyl alcohol / 16.5 h

2: sulfuric acid / n-heptane; dichloromethane / 6 h / 35 - 85 °C / Large scale

3: sodium iodide / butanone / 24 h / 80 °C / Large scale

4: sodium carbonate / water; butanone / 22.5 h / 75 - 80 °C / Large scale

With sodium tetrahydroborate; sulfuric acid; sodium carbonate; sodium iodide; In n-heptane; dichloromethane; water; isopropyl alcohol; butanone;
DOI:10.1021/op020211j

Reference yield:

: 637-59-2
1-Bromo-3-phenylpropane

: 76778-24-0
1-[2-[(4-fluorophenyl)(phenyl)methoxy]ethyl]-4-(3-phenylprypyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 8 h / 75 - 80 °C / Large scale

2: hydrogenchloride / ethanol / 2 h / 20 - 30 °C / Large scale

3: sodium carbonate / water; butanone / 22.5 h / 75 - 80 °C / Large scale

With hydrogenchloride; sodium carbonate; In ethanol; water; acetonitrile; butanone;
DOI:10.1021/op020211j