(1S,8aα)-Decahydro-5β-(1H-indol-3-ylmethyl)-1β,4aβ-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)naphthalen-2β-ol

Base Information

Chemical Name:(1S,8aα)-Decahydro-5β-(1H-indol-3-ylmethyl)-1β,4aβ-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)naphthalen-2β-ol
CAS No.:110883-37-9
Molecular Formula:C₂₈H₃₉NO
Molecular Weight:405.624
Hs Code.:
Mol file:110883-37-9.mol

Synonyms:2-Naphthalenol,decahydro-5-(1H-indol-3-ylmethyl)-1,4a-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)-,(1S,2S,4aR,5S,8aR)- (9CI); 2-Naphthalenol,decahydro-5-(1H-indol-3-ylmethyl)-1,4a-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)-,[1S-(1a,2b,4ab,5b,8aa)]-; (+)-Emindole SA; Emindole SA

Suppliers and Price of (1S,8aα)-Decahydro-5β-(1H-indol-3-ylmethyl)-1β,4aβ-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)naphthalen-2β-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (1S,8aα)-Decahydro-5β-(1H-indol-3-ylmethyl)-1β,4aβ-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)naphthalen-2β-ol

Chemical Property:

Boiling Point:544.9±50.0 °C(Predicted)
PKA:15.15±0.70(Predicted)
PSA：36.02000
Density:1.06±0.1 g/cm3(Predicted)
LogP:7.20650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1S,8aα)-Decahydro-5β-(1H-indol-3-ylmethyl)-1β,4aβ-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)naphthalen-2β-ol

There total 10 articles about (1S,8aα)-Decahydro-5β-(1H-indol-3-ylmethyl)-1β,4aβ-dimethyl-6-methylene-1-(4-methyl-3-pentenyl)naphthalen-2β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 323178-44-5
(1S,2S,4aR,5S,8aR)-5-(1-Benzenesulfonyl-1H-indol-3-ylmethyl)-1,4a-dimethyl-6-methylene-1-(4-methyl-pent-3-enyl)-decahydro-naphthalen-2-ol

: 110883-37-9
emindole SA

Guidance literature:: With lithium; diethylamine;
DOI:10.1016/S0040-4039(00)01528-8

Reference yield:

: 120-72-9
indole

: 110883-37-9
emindole SA

Guidance literature:: Multi-step reaction with 7 steps

1: EtMgBr / benzene / 20 °C

2: 72 percent / aq. KOH; Bu₄NHSO₄ / benzene / 20 °C

3: 83 percent / LDA; DMEU / tetrahydrofuran / -78 °C

4: 63 percent / EtNH₂; Li / methanol; diethyl ether / -78 °C

5: 95 percent / KOH; Bu₄NHSO₄

6: 20 percent / BF₃*Et₂O / CH₂Cl₂ / -40 °C

7: 75 percent / Et₂NH; Li

With 1,3-dimethyl-2-imidazolidinone; potassium hydroxide; boron trifluoride diethyl etherate; ethylmagnesium bromide; tetra(n-butyl)ammonium hydrogensulfate; lithium; ethylamine; diethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)01528-8

Reference yield:

: 64418-60-6
(E,E) O-acetyl 3,7-dimethyl-8-phenylsulfonyl-octa-2,6-diene-1-ol

: 110883-37-9
emindole SA

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / Na₂CO₃; MeOH

2: NBS; DMS / CH₂Cl₂ / -20 °C

3: EtMgBr / benzene / 20 °C

4: 72 percent / aq. KOH; Bu₄NHSO₄ / benzene / 20 °C

5: 83 percent / LDA; DMEU / tetrahydrofuran / -78 °C

6: 63 percent / EtNH₂; Li / methanol; diethyl ether / -78 °C

7: 95 percent / KOH; Bu₄NHSO₄

8: 20 percent / BF₃*Et₂O / CH₂Cl₂ / -40 °C

9: 75 percent / Et₂NH; Li

With 1,3-dimethyl-2-imidazolidinone; methanol; potassium hydroxide; N-Bromosuccinimide; 2,3-dimercapto-succinic acid; boron trifluoride diethyl etherate; ethylmagnesium bromide; tetra(n-butyl)ammonium hydrogensulfate; lithium; sodium carbonate; ethylamine; diethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)01528-8