3-({(2S)-3-(biphenyl-4-yl)-2-[(phosphonomethyl)amino]propanoyl}amino)propanoic acid (non-preferred name)

Base Information

Chemical Name:3-({(2S)-3-(biphenyl-4-yl)-2-[(phosphonomethyl)amino]propanoyl}amino)propanoic acid (non-preferred name)
CAS No.:147861-76-5
Molecular Formula:C₁₉H₂₃N₂O₆P
Molecular Weight:406.375
Hs Code.:
Mol file:147861-76-5.mol

Synonyms:b-Alanine,N-[3-[1,1'-biphenyl]-4-yl-N-(phosphonomethyl)-DL-alanyl]-; CGS 24128

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Chemical Property of 3-({(2S)-3-(biphenyl-4-yl)-2-[(phosphonomethyl)amino]propanoyl}amino)propanoic acid (non-preferred name)

Chemical Property:

Density:1.359g/cm³

Purity/Quality:

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Technology Process of 3-({(2S)-3-(biphenyl-4-yl)-2-[(phosphonomethyl)amino]propanoyl}amino)propanoic acid (non-preferred name)

There total 6 articles about 3-({(2S)-3-(biphenyl-4-yl)-2-[(phosphonomethyl)amino]propanoyl}amino)propanoic acid (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 147861-77-6
tert-butyl (S)-3-amino>-3-(4-biphenylyl)propionyl>amino>propionate

: 147861-76-5
CGS 24592

Guidance literature:: With hydrogen bromide; In acetic acid; for 6.5h; Ambient temperature;

Reference yield:

: 147923-07-7
t-butyl N-[2-(dimethylphosphonomethylamino)-3-(4-biphenylyl)-propionyl]-3-aminopropionate

: 147861-76-5
N-[2-(phosphonomethylamino)-3-(4-biphenylyl)-propionyl]-3-aminopropionic acid

Guidance literature:: In glacial HOAc; water; hydrogen bromide;

Reference yield:

: (S)-4-phenylphenylalanine benzyl ester

: 147861-76-5
CGS 24592

Guidance literature:: Multi-step reaction with 4 steps

1: 92.5 percent / diisopropylethylamine / CH₂Cl₂ / 18 h / Ambient temperature

2: 88 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 2585.7 Torr

3: 90 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), N-<3-(dimethylamino)propyl>-N'-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 3 h

4: 51 percent / 30percent HBr / acetic acid / 6.5 h / Ambient temperature

With hydrogen bromide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;