N-(3,4-Difluorophenyl)acetamide

Base Information

Chemical Name:N-(3,4-Difluorophenyl)acetamide
CAS No.:458-11-7
Molecular Formula:C8H7F2NO
Molecular Weight:171.146
Hs Code.:2924299090
European Community (EC) Number:610-272-8
NSC Number:10347
DSSTox Substance ID:DTXSID30278856
Nikkaji Number:J355.001J
Wikidata:Q82011023
Mol file:458-11-7.mol

Synonyms:N-(3,4-Difluorophenyl)acetamide;458-11-7;3',4'-Difluoroacetanilide;3,4-difluoroacetanilide;NSC10347;SCHEMBL863069;DTXSID30278856;N-(3,4-difluoro-phenyl)acetamide;N-(3,4-Difluoro-phenyl)-acetamide;MFCD00017903;NSC-10347;AKOS003867658;PS-8689;CS-0199429;FT-0614847

Suppliers and Price of N-(3,4-Difluorophenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3'',4''-Difluoroacetanilide
50mg
$ 45.00

SynQuest Laboratories
3,4-Difluoroacetanilide 97%
1 g
$ 18.00

Sigma-Aldrich
3',4'-DIFLUOROACETANILIDE Aldrich
250mg
$ 33.40

Crysdot
N-(3,4-Difluorophenyl)acetamide 97%
100g
$ 463.00

American Custom Chemicals Corporation
3',4'-DIFLUOROACETANILIDE 95.00%
5G
$ 925.39

American Custom Chemicals Corporation
3',4'-DIFLUOROACETANILIDE 95.00%
1G
$ 647.36

AK Scientific
3',4'-Difluoroacetanilide
25g
$ 325.00

AK Scientific
3',4'-Difluoroacetanilide
1g
$ 35.00

AHH
3,4-Difluoroacetanilide 97%
10g
$ 406.00

Total 26 raw suppliers

Chemical Property of N-(3,4-Difluorophenyl)acetamide

Chemical Property:

Vapor Pressure:0.00198mmHg at 25°C
Melting Point:127-127.5 °C
Refractive Index:1.531
Boiling Point:291.2 °C at 760 mmHg
PKA:13.32±0.70(Predicted)
Flash Point:129.9 °C
PSA：29.10000
Density:1.307 g/cm³
LogP:1.99620
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:171.04957017
Heavy Atom Count:12
Complexity:174

Purity/Quality:

99% ^*data from raw suppliers

3'',4''-Difluoroacetanilide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(=O)NC1=CC(=C(C=C1)F)F

Technology Process of N-(3,4-Difluorophenyl)acetamide

There total 15 articles about N-(3,4-Difluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 108-24-7
acetic anhydride

: 3863-11-4
3,4-difluoroaniline

: 458-11-7
3,4-difluoroacetanilide

Guidance literature:: In 1,4-dioxane; at 0 ℃; for 1h; Inert atmosphere; Schlenk technique;
DOI:10.1039/c8tc05764h

Reference yield: 85.0%

: 141-32-2,9003-49-0
acrylic acid n-butyl ester

: 1182601-99-5
N-(3,4-difluoro-2-(trimethylsilyl)phenyl)acetamide

: 1182602-21-6
butyl (E)-3-(6-acetamido-2,3-difluorophenyl)acrylate

: 458-11-7
3,4-difluoroacetanilide

Guidance literature:: With palladium diacetate; toluene-4-sulfonic acid; p-benzoquinone; In acetone; at 20 ℃; for 40h; regioselective reaction; Inert atmosphere;
DOI:10.1039/b905717j