Cyclopropylamine

Base Information

• Chemical Name: Cyclopropylamine
• CAS No.: 765-30-0
• Molecular Formula: C3H7N
• Molecular Weight: 57.0953
• Hs Code.: 29213099
• European Community (EC) Number: 212-142-2
• NSC Number: 56127
• UNII: 8PR8XTH1X1
• DSSTox Substance ID: DTXSID9061099
• Nikkaji Number: J79.937H
• Wikidata: Q1147604
• Metabolomics Workbench ID: 55009
• Mol file: 765-30-0.mol

Synonyms:cyclopropylamine;cyclopropylamine acetate;cyclopropylamine hydrochloride;cyclopropylamine, 3H-labeled

Chemical Property of Cyclopropylamine

Chemical Property:

• Appearance/Colour: Clear and colourless, volatile liquid
• Vapor Pressure: 4.67 psi ( 20 °C)
• Melting Point: -50 °C
• Refractive Index: 1.4206
• Boiling Point: 49.3 °C at 760 mmHg
• PKA: pK1:9.10(+1) (25°C)
• Flash Point: -14 °F
• PSA: 26.02000
• Density: 0.938 g/cm³
• LogP: 0.80780
• Storage Temp.: Flammables area
• Sensitive.: Lachrymatory
• Water Solubility.: Miscible with water, ethanol,ether and chloroform.
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 57.057849228
• Heavy Atom Count: 4
• Complexity: 22.5

Purity/Quality:

99% ^*data from raw suppliers

Cyclopropylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, C, Xi
• Hazard Codes: F,C,Xi
• Statements: 11-22-34-36/37
• Safety Statements: 16-26-36/37/39-45-33-7/9

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC1N
• Uses: Cyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.

Technology Process of Cyclopropylamine

There total 37 articles about Cyclopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

nitrocyclopropane (13021-02-8) → Cyclopropylamine (765-30-0)

Guidance literature:

With triethylamine; In water; at 80 ℃; for 6h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1039/c4ra01333f

Reference yield: 83.0%

Cyclopropancarbamid (6228-73-5) → Cyclopropylamine (765-30-0)

Guidance literature:

Reference yield: 82.0%

→ Cyclopropylamine (765-30-0)

Guidance literature:

With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 40 ℃; for 24h;

upstream raw materials:

nitrocyclopropane

Cyclopropancarbamid

Methyl N-cyclopropylcarbamate

cyclopropanecarboxylic acid

Downstream raw materials:

1-Cyclopropyl-3-(4-nitrophenyl)-harnstoff

[(cyclopropyl)amino]acetic acid ethyl ester

2-cyano-N-cyclopropylacetamide

2-(cyclopropylamino)-1-phenylethanone

Refernces

• 1、 -. "Novel method and technology for synthesizing cyclopropyl ammonia". Paragraph 0019. . Retrieved 2021/09/21.
• 2、 Sun, Zheming,Chen, Jiangbo,Tu, Tao. "NHC-based coordination polymers as solid molecular catalysts for reductive amination of biomass levulinic acid". . p. 789 - 794. Retrieved 2017/08/18.