4-TERT-BUTYLPHENOXYACETYL CHLORIDE

Base Information

• Chemical Name: 4-TERT-BUTYLPHENOXYACETYL CHLORIDE
• CAS No.: 90734-55-7
• Molecular Formula: C12H15 Cl O2
• Molecular Weight: 226.703
• Hs Code.: 2918990090
• Mol file: 90734-55-7.mol

Synonyms:Acetylchloride, [4-(1,1-dimethylethyl)phenoxy]- (9CI); (4-tert-Butylphenoxy)acetylchloride; (p-tert-Butylphenoxy)acetyl chloride; 2-[4-(tert-Butyl)phenoxy]acetylchloride

Chemical Property of 4-TERT-BUTYLPHENOXYACETYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.00211mmHg at 25°C
• Refractive Index: 1.5162 (589.3 nm 20℃)
• Boiling Point: 290.1°Cat760mmHg
• Flash Point: 108.1°C
• PSA: 26.30000
• Density: 1.105g/cm³
• LogP: 3.12830
• Sensitive.: Moisture Sensitive
• Water Solubility.: Reacts with water.

Purity/Quality:

97% ^*data from raw suppliers

(4-tert-Butylphenoxy)acetyl chloride ^*data from reagent suppliers

Safty Information:

• Statements: 14-34
• Safety Statements: 26-27-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-tert-Butylphenoxyacetyl chloride is used as a reagent and as intermediates.

Technology Process of 4-TERT-BUTYLPHENOXYACETYL CHLORIDE

There total 4 articles about 4-TERT-BUTYLPHENOXYACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4-tert-butylphenoxy)acetic acid (1798-04-5) → (4-tert-butylphenoxy)acetyl chloride (90734-55-7)

Guidance literature:

With thionyl chloride; In benzene; for 3h; Reflux;

DOI:10.1021/jm400221d

Reference yield: 95.0%

→ (4-tert-butylphenoxy)acetyl chloride (90734-55-7)

Guidance literature:

Reference yield:

para-tert-butylphenol (98-54-4) → (4-tert-butylphenoxy)acetyl chloride (90734-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: thionyl chloride / benzene / 3 h / Reflux

With thionyl chloride; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm400221d

upstream raw materials:

(4-tert-butylphenoxy)acetic acid

para-tert-butylphenol

tert-butyl 2-(4-tert-butylphenoxy)acetate

Downstream raw materials:

(4-tert-butyl-phenoxy)-acetic acid-(3-oxo-androst-4-en-17β-yl ester)

4-tert.-Butyl-phenoxyessigsaeure-<2-dimethylamino-aethylester>

(6'aS,7'S,8'R,9'aR)-N-(8'-benzyloxy-7'-benzyloxymethyl-7',8',9',9'a-tetrahydro-6'aH-cyclopenta[4,5]oxazolo[3,2-e]purin-4'-yl)-2-(4-tert-butylphenoxy)acetamide

10-[(4-tert-Butylphenoxy)acetyl]-N-(pyridin-3-ylmethyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxamide