2-hydroxyaldosterone

Base Information

• Chemical Name: 2-hydroxyaldosterone
• CAS No.: 147199-27-7
• Molecular Formula: C₂₁H₂₈O₆
• Molecular Weight: 376.45
• Mol file: 147199-27-7.mol

Synonyms:11,13-(Epoxymethano)-13H-cyclopenta[a]phenanthrene,pregn-4-ene-3,20-dione deriv.

Chemical Property of 2-hydroxyaldosterone

Chemical Property:

• Vapor Pressure: 1.64E-17mmHg at 25°C
• Boiling Point: 611.6°C at 760 mmHg
• PKA: 12.56±0.70(Predicted)
• Flash Point: 337.7°C
• PSA: 104.06000
• Density: 1.34g/cm³
• LogP: 0.97390

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxyaldosterone

There total 4 articles about 2-hydroxyaldosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(20R)-2β-hydroxyaldosterone-20,21-acetonide → 2β-hydroxyaldosterone (147199-27-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1.5h; Ambient temperature; pH = 1;

DOI:10.1016/0039-128X(93)90053-P

Reference yield: 42.0%

(20R)-2α-hydroxyaldosterone-20,21-acetonide → 2α-hydroxyaldosterone (147199-27-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1.5h; Ambient temperature; pH = 1;

DOI:10.1016/0039-128X(93)90053-P

Reference yield:

C26H34O7 → 2β-hydroxyaldosterone (147199-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 19.3 mg / 0.1 M NaHCO₃ / methanol / 3 h / Ambient temperature

2: 55 percent / aq. HCl / dioxane / 1.5 h / Ambient temperature; pH = 1

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; methanol;

DOI:10.1016/0039-128X(93)90053-P

Refernces