Clodinafop-Propargyl

Base Information

• Chemical Name: Clodinafop-Propargyl
• CAS No.: 105512-06-9
• Deprecated CAS: 126301-94-8,126572-25-6,674310-99-7,934237-35-1,126572-25-6,674310-99-7,934237-35-1
• Molecular Formula: C₁₇H₁₃ClFNO₄
• Molecular Weight: 349.746
• Hs Code.: 29333990
• European Community (EC) Number: 600-662-6
• UNII: QEH394TY6Y
• DSSTox Substance ID: DTXSID6032354
• Nikkaji Number: J669.726G
• Wikidata: Q1102118
• Metabolomics Workbench ID: 143654
• ChEMBL ID: CHEMBL1898102
• Mol file: 105512-06-9.mol

Synonyms:clodinafop-propargyl

Chemical Property of Clodinafop-Propargyl

Chemical Property:

• Appearance/Colour: White crystal powder.
• Melting Point: 48-57 °C
• Boiling Point: 432.7 °C at 760 mmHg
• PKA: -1.54±0.32(Predicted)
• Flash Point: 215.5 °C
• PSA: 57.65000
• Density: 1.326 g/cm³
• LogP: 3.61010
• Storage Temp.: 0-6°C
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 349.0517138
• Heavy Atom Count: 24
• Complexity: 461

Purity/Quality:

99% ^*data from raw suppliers

ClodinafopPropargyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn;N,N,Xn
• Statements: 20/22-43-50/53-48/22
• Safety Statements: 36/37-60-61-46-24

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Pesticides -> Herbicides, Other
• Canonical SMILES: CC(C(=O)OCC#C)OC1=CC=C(C=C1)OC2=C(C=C(C=N2)Cl)F
• Isomeric SMILES: C[C@H](C(=O)OCC#C)OC1=CC=C(C=C1)OC2=C(C=C(C=N2)Cl)F
• Description: Clodinafop-propargyl is a foliar-absorbed aryloxyphenoxypropionate herbicide which has the capacity to inhibit the lipid biosynthesizing enzyme, acetyl coenzyme-A-carboxylase.Clodinafop-propargyl is a member of the Oxyphenoxy acid ester chemical class, which includes the active ingredients fluazifop-butyl, fenoxaprop-ethyl, diclofop methyl, quizalofop-ethyl and haloxyfop-methyl.
• Uses: Clodinafop-propargyl is a member of the aryloxyphenoxy propionate chemical family. It acts as a systemic herbicide that acts on post-emergent weeds such as selected grasses. It does not act on broad leaved weeds. It is applied to the foliar parts of the weeds and is absorbed through the leaves. This foliar acting grass weed killer is translocated to the meristematic growing points of the plant where it interferes with the production of fatty acids required for plant growth.Grass weeds controlled include wild oats, rough meadow-grass, green foxtail, barnyard grass, Persian darnel, volunteer canary seed. It also provides moderate control of Italian rye-grass. It is suitable for use on the following crops – all varieties of wheat, autumn-sown spring wheat, rye, triticale and durum wheat. Herbicides for weed control in wheat.

Technology Process of Clodinafop-Propargyl

There total 8 articles about Clodinafop-Propargyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-chloro-2,3-difluoropyridine (89402-43-7) + 2-(4-hydroxyphenoxy)propionic acid-2-propynyl ester → 2-[4-(5-chloro-3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid propargyl ester (105512-06-9)

Guidance literature:

With potassium hydroxide; In toluene; at 70 - 75 ℃; for 10h; Time; Inert atmosphere;

Reference yield: 94.4%

clodinafop (114420-56-3) + propargyl alcohol (107-19-7) → 2-propynyl (R)-2-[4-(5-chloro-3-fluoro-2-pyridinyloxy)-phenoxy]-propionate (105512-06-9)

Guidance literature:

With (2,3,4,5,6-pentafluorophenyl)ammonium triflate; In toluene; at 80 ℃; for 12h; Solvent; Reagent/catalyst; Concentration; Temperature; Large scale;

Reference yield: 91.3%

clodinafop (114420-56-3) + 2-propynyl chloride (624-65-7) → 2-propynyl (R)-2-[4-(5-chloro-3-fluoro-2-pyridinyloxy)-phenoxy]-propionate (105512-06-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 65 ℃; for 4h; Temperature;

upstream raw materials:

clodinafop

propargyl alcohol

5-chloro-2,3-difluoropyridine

(R)-2-(4-hydroxyphenoxy)propionic acid

Refernces

• 1、 -. "NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING AMIDE COMPOUND". . . Retrieved 2017/08/26.