Technology Process of 1-[3-[1,6-Dihydro-5-(2-methylpropyl)-6-oxopyrazin-1-yl]propyl]guanidine
There total 5 articles about 1-[3-[1,6-Dihydro-5-(2-methylpropyl)-6-oxopyrazin-1-yl]propyl]guanidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C17H33N5O4;
With
hydrogenchloride;
In
methanol; water monomer;
for 3h;
With
sodium hydroxide;
In
methanol; water monomer;
for 2h;
pH=Ca. 10;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: borane-THF / tetrahydrofuran / -78 °C
2.1: hydrogenchloride / water monomer; methanol / 4 h / 0 - 20 °C
3.1: benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
4.1: acetic acid / dichloromethane / 0.17 h / Inert atmosphere
4.2: 20 °C
5.1: Dess-Martin periodane / dichloromethane / 0 °C
6.1: hydrogenchloride / water monomer; methanol / 3 h
6.2: 2 h / pH Ca. 10
With
hydrogenchloride; borane-THF; benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water monomer; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water monomer; methanol / 4 h / 0 - 20 °C
2.1: benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
3.1: acetic acid / dichloromethane / 0.17 h / Inert atmosphere
3.2: 20 °C
4.1: Dess-Martin periodane / dichloromethane / 0 °C
5.1: hydrogenchloride / water monomer; methanol / 3 h
5.2: 2 h / pH Ca. 10
With
hydrogenchloride; benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; acetic acid; triethylamine;
In
methanol; dichloromethane; water monomer; N,N-dimethyl-formamide;
