2-methyl-2-phenylpropan-1-amine

Base Information

• Chemical Name: 2-methyl-2-phenylpropan-1-amine
• CAS No.: 21404-88-6
• Molecular Formula: C10H15 N
• Molecular Weight: 149.236
• Hs Code.: 2921499090
• Mol file: 21404-88-6.mol

Synonyms:Phenethylamine,b,b-dimethyl- (8CI); 2-Methyl-2-phenyl-1-propylamine;2-Methyl-2-phenylpropaneamine; NSC 28722; b,b-Dimethylbenzeneethanamine

Chemical Property of 2-methyl-2-phenylpropan-1-amine

Chemical Property:

• Vapor Pressure: 0.111mmHg at 25°C
• Boiling Point: 220.8°Cat760mmHg
• PKA: 9.98±0.10(Predicted)
• Flash Point: 92.4°C
• PSA: 26.02000
• Density: 0.933g/cm³
• LogP: 2.62320

Purity/Quality:

96% ^*data from raw suppliers

2-methyl-2-phenylpropan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-2-phenylpropan-1-amine

There total 11 articles about 2-methyl-2-phenylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetonitrile (140-29-4) → 2-methyl-2-phenylpropylamine (21404-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide; diethyl ether / 20 h / Ambient temperature

2: H₂, NH₃ / Raney Ni / methanol / 40 h / 20 - 40 °C / 2585.7 Torr

With ammonia; hydrogen; sodium hydride; nickel; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm00074a011

Reference yield:

1-Amino-2-methyl-propan-2-ol (2854-16-2) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-methyl-2-phenylpropylamine (21404-88-6)

Guidance literature:

With aluminium trichloride;

DOI:10.1021/ja01245a009

Reference yield:

2-methyl-2-phenyl-propanamide (826-54-0) → 2-methyl-2-phenylpropylamine (21404-88-6)

Guidance literature:

With ethanol; sodium;

upstream raw materials:

2-methyl-2-phenyl-propanamide

2-methyl-1-nitro-2-phenylpropane

1-Amino-2-methyl-propan-2-ol

benzene

Downstream raw materials:

2-fluoro-N'-hydroxy-6-methoxy-N-(2-methyl-2-phenylpropyl)benzamidine

2-methyl-2-phenylpropionitrile

2,2-(dimethyl)-2-phenylacetaldehyde

4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-2-phenylpropyl)-6-morpholino-1,3,5-triazin-2-amine

Refernces

• 1、 Trivedi, Bharat K.,Holmes, Ann,Stoeber, Terri L.,Blankley, C. John,Roark, W. Howard,et al.. "Inhibitors of Acyl-CoA:Cholesterol Acyltransferase. 4. A Novel Series of Urea ACAT Inhibitors as Potential Hypocholesterolemic Agents". . p. 3300 - 3307. Retrieved 2007/10/02.