2-tert-butyl-7-(2,4-dichlorophenyl)octahydro-2H-quinolizin-2-ol

Base Information

Chemical Name:2-tert-butyl-7-(2,4-dichlorophenyl)octahydro-2H-quinolizin-2-ol
CAS No.:87922-67-6
Molecular Formula:C₁₉H₂₇Cl₂NO
Molecular Weight:356.335
Hs Code.:2903999090
Mol file:87922-67-6.mol

Synonyms:2H-Quinolizin-2-ol,7-(2,4-dichlorophenyl)-2-(1,1-dimethylethyl)octahydro-, (2a,7a,9aa)- (9CI); 2H-Quinolizin-2-ol,7-(2,4-dichlorophenyl)-2-(1,1-dimethylethyl)octahydro-, (2a,7a,9aa)-(?à)-

Suppliers and Price of 2-tert-butyl-7-(2,4-dichlorophenyl)octahydro-2H-quinolizin-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2-tert-butyl-7-(2,4-dichlorophenyl)octahydro-2H-quinolizin-2-ol

Chemical Property:

Vapor Pressure:5.6E-09mmHg at 25°C
Boiling Point:452.5°C at 760 mmHg
Flash Point:227.5°C
PSA：23.47000
Density:1.21g/cm³
LogP:5.05030

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-tert-butyl-7-(2,4-dichlorophenyl)octahydro-2H-quinolizin-2-ol

There total 5 articles about 2-tert-butyl-7-(2,4-dichlorophenyl)octahydro-2H-quinolizin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87922-75-6
5-(2,4-Dichloro-phenyl)-piperidin-2-one

: 87922-67-6
(2S,7R,9aR)-2-tert-Butyl-7-(2,4-dichloro-phenyl)-octahydro-quinolizin-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) aq. K₂CO₃ / 1.) CH₂Cl₂, a) reflux, 4 h, b) RT, 15 h, 2.) CH₂Cl₂, RT, 2 h

2: p-toluenesulfonic acid / methanol / 20 h / Ambient temperature

3: diisobutylaluminum hydride / 1,2-dimethoxy-ethane; toluene / 1 h / -30 - -20 °C

4: 6 N HCl / 3 h / Heating

5: tetrahydrofuran; pentane / 0.5 h / -75 °C

With hydrogenchloride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; toluene; pentane;
DOI:10.1021/jm00368a011

Reference yield:

: 87922-83-6
3-(2,4-Dichloro-phenyl)-6-ethoxy-2,3,4,5-tetrahydro-pyridine

: 87922-67-6
(2S,7R,9aR)-2-tert-Butyl-7-(2,4-dichloro-phenyl)-octahydro-quinolizin-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / methanol / 20 h / Ambient temperature

2: diisobutylaluminum hydride / 1,2-dimethoxy-ethane; toluene / 1 h / -30 - -20 °C

3: 6 N HCl / 3 h / Heating

4: tetrahydrofuran; pentane / 0.5 h / -75 °C

With hydrogenchloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; toluene; pentane;
DOI:10.1021/jm00368a011

Reference yield:

: 75385-10-3
7-(2,4-Dichloro-phenyl)-2-oxo-3,4,6,7,8,9-hexahydro-2H-quinolizine-1-carboxylic acid methyl ester

: 87922-67-6
(2S,7R,9aR)-2-tert-Butyl-7-(2,4-dichloro-phenyl)-octahydro-quinolizin-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminum hydride / 1,2-dimethoxy-ethane; toluene / 1 h / -30 - -20 °C

2: 6 N HCl / 3 h / Heating

3: tetrahydrofuran; pentane / 0.5 h / -75 °C

With hydrogenchloride; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; pentane;
DOI:10.1021/jm00368a011