Fapgg

Base Information

• Chemical Name: Fapgg
• CAS No.: 64967-39-1
• Molecular Formula: C20H21 N3 O6
• Molecular Weight: 399.403
• Hs Code.: 29321900
• Nikkaji Number: J503.890A

Synonyms:2-furanacryloyl-phenylalanyl-glycyl-glycine;3-(2-furylacryloyl)phenylalanyl-glycyl-glycine;FA-Phe-Gly-Gly;FAPGG

Chemical Property of Fapgg

Chemical Property:

• Appearance/Colour: OFF-WHITE TO LIGHT TAN POWDER
• Vapor Pressure: 3.9E-30mmHg at 25°C
• Melting Point: 245 °C (dec.)(lit.)
• Boiling Point: 842.3 °C at 760 mmHg
• PKA: 3.32±0.10(Predicted)
• Flash Point: 463.2 °C
• PSA: 137.74000
• Density: 1.321 g/cm³
• LogP: 1.51000
• Storage Temp.: −20°C
• Solubility.: NH4OH 1 M: 50 mg/mL, clear to slightly turbid, yellow
• XLogP3: 1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 399.14303540
• Heavy Atom Count: 29
• Complexity: 615

Purity/Quality:

98%, ^*data from raw suppliers

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C(=O)NCC(=O)NCC(=O)O)NC(=O)C=CC2=CC=CO2
• Isomeric SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)NCC(=O)NCC(=O)O)NC(=O)/C=C/C2=CC=CO2
• Uses: A substrate for the continuous sprectrophotometric assay of ACE. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly has been used for kinetic spectrophotometric assay of ACE (angiotensin converting enzyme) inhibitory activity.

Technology Process of Fapgg

There total 6 articles about Fapgg which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Nα-furylacryloylphenylalanylglycylglycine ethyl ester (103972-53-8) → N?[3?(2?furyl)acryloyl]-L-phenylalanylglycylglycine (64967-39-1)

Guidance literature:

With potassium hydroxide; In methanol; for 5h;

Reference yield:

quinolin-8-yl ester of N-benzyloxycarbonyl-L-phenylalanine (2440-94-0) → N?[3?(2?furyl)acryloyl]-L-phenylalanylglycylglycine (64967-39-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / triethylamine, N-hydroxybenzotriazole / dimethylformamide / 16 h

2: 93 percent / 4M HBr / acetic acid / 1 h

3: 82 percent / triethylamine / CH₂Cl₂ / 0.5 h

4: 76 percent / 1M KOH / methanol / 5 h

With potassium hydroxide; hydrogen bromide; benzotriazol-1-ol; triethylamine; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

(E)-3-(furan-2-yl)acrylic anhydride (67998-15-6) → N?[3?(2?furyl)acryloyl]-L-phenylalanylglycylglycine (64967-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / triethylamine / CH₂Cl₂ / 0.5 h

2: 76 percent / 1M KOH / methanol / 5 h

With potassium hydroxide; triethylamine; In methanol; dichloromethane;

upstream raw materials:

N^α-furylacryloylphenylalanylglycylglycine ethyl ester

quinolin-8-yl ester of N-benzyloxycarbonyl-L-phenylalanine

(E)-3-(furan-2-yl)acrylic anhydride

N^α-benzyloxycarbonylphenylalanylglycylglycine ethyl ester

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