paroxetine Mesylate

Base Information

• Chemical Name: paroxetine Mesylate
• CAS No.: 217797-14-3
• Molecular Formula: C20H25NO6S
• Molecular Weight: 425.478
• European Community (EC) Number: 688-144-6
• UNII: M711N184JE
• DSSTox Substance ID: DTXSID10944385
• NCI Thesaurus Code: C47653
• RXCUI: 436212
• ChEMBL ID: CHEMBL1200609
• Mol file: 217797-14-3.mol

Synonyms:POT.mes;Paroxetine Mesylate [USAN];Paroxetine Mesylate;Paroxetine methanesulfonate;Pexeva;(3S,4R)-3-(benzo[1,3]dioxol-5-yloxymethyl)-4-phenyl-piperidine; methanesulfonic acid;

Chemical Property of paroxetine Mesylate

Chemical Property:

• Vapor Pressure: 2.03E-08mmHg at 25°C
• Boiling Point: 453.6°C at 760 mmHg
• Flash Point: 189.2°C
• PSA: 102.47000
• LogP: 4.10100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 425.13083682
• Heavy Atom Count: 29
• Complexity: 495

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidinemethanesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)O.C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
• Isomeric SMILES: CS(=O)(=O)O.C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
• Recent ClinicalTrials: Eight-Week Efficacy & Safety Study of Brisdelle? (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms Associated With Menopause
• Uses: Treatment of major depressive disorder, obsessive compulsive disorder, and panic disorder (selective serotonin reuptake inhibitor). Paroxetine Mesylate is a selective serotonin reuptake inhibitor in treatment of depression in human, dog, cat, horse and parrot.

Technology Process of paroxetine Mesylate

There total 2 articles about paroxetine Mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylic acid phenyl ester (253768-88-6) → paroxetine mesylate (217797-14-3)

Guidance literature:

With potassium hydroxide; methanesulfonic acid; In toluene;

Reference yield:

→ paroxetine mesylate (217797-14-3)

Guidance literature:

upstream raw materials:

(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylic acid phenyl ester