Plasmin

Base Information

• Chemical Name: Plasmin
• CAS No.: 9001-90-5
• Molecular Weight: 0
• Mol file: 9001-90-5.mol

Synonyms:Actase; E.C.3.4.21.7; E.C. 3.4.4.14; Fibrinase; Fibrinolysin; Serum tryptase; TAL 05-00018;Thrombolysin

Chemical Property of Plasmin

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Plasmin, Human Plasma ^*data from reagent suppliers

Safty Information:

• Hazard Codes: B,Xn
• Statements: 36/37/38-42
• Safety Statements: 2-22-24-26-36/37-45-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Plasmin is present in blood to prevent unwanted clotting by catalysing the breakdown of the fibrin polymer that provides the framework of a blood clot. Plasmin is formed from plasminogen, a process that occurs after plasminogen has been activated by forming a complex with fibrin. After certain tissue fragments had been shown to possess plasminogenactivating ability, a soluble fraction possessing this activity was extracted and purified. Cloning and expression of complementary DNA (cDNA) for human tissue-type plasminogen activator permitted commercial production of alteplase. Alteplase was shown to be a potent thrombolytic agent by virtue of its ability to activate plasminogen, thus breaking down fibrin in the thrombus. An early clinical study in patients with coronary occlusion following myocardial infarction showed that it was an effective drug for dissolving clots in coronary arteries. It was marketed for this purpose in 1988. Human plasmin has been used as an oligopeptide substrate in peptidase inhibition assays. A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. It has also been used in a study to investigate activation of human epithelial sodium channel (ENaC) by plasmin and chymotrypsin.