(L-LEUCINETHIOL)2 2 HCL

Base Information

• Chemical Name: (L-LEUCINETHIOL)2 2 HCL
• CAS No.: 112157-33-2
• Molecular Formula: C12H28 N2 S2 . 2 Cl H
• Molecular Weight: 337.42
• Mol file: 112157-33-2.mol

Synonyms:2-Pentanamine,1,1'-dithiobis[4-methyl-, dihydrochloride, [S-(R*,R*)]- (9CI)

Chemical Property of (L-LEUCINETHIOL)2 2 HCL

Chemical Property:

• Vapor Pressure: 3.13E-05mmHg at 25°C
• Boiling Point: 355.4°Cat760mmHg
• Flash Point: 168.7°C
• PSA: 102.64000
• Density: g/cm³
• LogP: 6.11920
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

(L-Leucinethiol)2Dihydrochloride(disulfidebond) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (L-LEUCINETHIOL)2 2 HCL

There total 6 articles about (L-LEUCINETHIOL)2 2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[(S)-1-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentyldisulfanylmethyl)-3-methyl-butyl]-carbamic acid tert-butyl ester (112157-32-1) → (H-Leu(CH2S)-)2*2HCl (112157-33-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00119a022

Reference yield:

(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester (82010-31-9) → (H-Leu(CH2S)-)2*2HCl (112157-33-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / TEA / CH₂Cl₂

2: 97 percent / dimethylformamide

3: 91 percent / aq. NaOH

4: 91 percent / HCl

With hydrogenchloride; sodium hydroxide; TEA; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00119a022

Reference yield:

(S)-(-)-1,1-dimethylethyl <3-methyl-1-<<(methylsulfonyl)oxy>methyl>butyl>carbamate (109687-65-2) → (H-Leu(CH2S)-)2*2HCl (112157-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / dimethylformamide

2: 91 percent / aq. NaOH

3: 91 percent / HCl

With hydrogenchloride; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00119a022

upstream raw materials:

[(S)-1-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentyldisulfanylmethyl)-3-methyl-butyl]-carbamic acid tert-butyl ester

(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester

(S)-(-)-1,1-dimethylethyl <3-methyl-1-<<(methylsulfonyl)oxy>methyl>butyl>carbamate

thioacetic acid S-((S)-2-tert-butoxycarbonylamino-4-methyl-pentyl) ester

Downstream raw materials:

(S)-2-Amino-N-{(S)-1-[(S)-2-((S)-2-amino-3-phenyl-propionylamino)-4-methyl-pentyldisulfanylmethyl]-3-methyl-butyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid

Refernces

• 1、 Kondo, Michio,Uchida, Hiroaki,Kodama, Hiroaki,Kitajima, Hiroshi,Shimohigashi, Yasuyuki. "Synthesis of Enkephalin Analog with Leucinthiol at C-terminus as Probe for Thiol Group In Opiate Receptors". . p. 997 - 1000. Retrieved 2007/10/02.