Chemical Property of [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 2-methylbutanoate;[(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
Chemical Property:
- Vapor Pressure:4.41E-25mmHg at 25°C
- Melting Point:149.5℃
- Refractive Index:1.5800 (estimate)
- Boiling Point:777.8°C at 760 mmHg
- Flash Point:424.2°C
- PSA：157.33000
- Density:1.22g/cm3
- LogP:4.58020
- Storage Temp.:−20°C
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:18
- Rotatable Bond Count:24
- Exact Mass:1096.54676172
- Heavy Atom Count:78
- Complexity:1700
- Purity/Quality:
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97% *data from raw suppliers
AntimycinA1 ≥98.0% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:T
- Statements:
23/24/25
- Safety Statements:
36/37/39-45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C.CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)C(C)CC
- Isomeric SMILES:CCCCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C.CCCCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)C(C)CC
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Description
Antimycin A1 is an active component of the antimycin A antibiotic complex. It inhibits electron transport and is active against the plant pathogenic fungus G. cingulate. Antimycin A1 (3.3-160 μM) induces the synthesis of carotenoids in M. marinum. It also inhibits ATP-citrate lyase (Ki = 29.5 μM).
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Uses
Antimycin A1 is the most hydrophobic of the four analogues of the antimycin A complex. Like all antimycins, antimycin A1 exhibits potent antifungal, anthelmintic, insecticidal, antiviral and antitumor activity across a range of bioassays. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes. Antimycin A1 inhibits angiogenesis via a decrease in VEGF production caused by inhibition of HIF-1a activation. Experimentally as fungicide, insecticide, miticide.
