2-Phenoxybenzhydrazide

Base Information

• Chemical Name: 2-Phenoxybenzhydrazide
• CAS No.: 43038-37-5
• Molecular Formula: C13H12N2O2
• Molecular Weight: 228.25
• European Community (EC) Number: 671-401-1
• DSSTox Substance ID: DTXSID20195649
• Wikidata: Q83068667
• Mol file: 43038-37-5.mol

Synonyms:2-Phenoxybenzhydrazide;2-Phenoxybenzohydrazide;43038-37-5;2-Phenoxybenzoic acid hydrazide;phenoxybenzohydrazide;2-Phenoxybenzohydrazide #;SCHEMBL3650651;2-phenoxy-benzoic acid hydrazide;DTXSID20195649;Benzoic acid,2-phenoxy-,hydrazide;2-phenoxybenzhydrazide, AldrichCPR;MFCD00017048;AKOS015855100;FS-4713;SB85927;FT-0682057;P2357;D95425;A826114

Chemical Property of 2-Phenoxybenzhydrazide

Chemical Property:

• Melting Point: 99 °C
• Refractive Index: 1.612
• PKA: 12.18±0.10(Predicted)
• PSA: 64.35000
• Density: 1.217 g/cm³
• LogP: 3.17360
• Solubility.: soluble in Methanol
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.089877630
• Heavy Atom Count: 17
• Complexity: 252

Purity/Quality:

98%min ^*data from raw suppliers

2-Phenoxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-43-36
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=CC=CC=C2C(=O)NN

Technology Process of 2-Phenoxybenzhydrazide

There total 4 articles about 2-Phenoxybenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenoxybenzoic acid (2243-42-7) → 2-phenoxybenzoic acid hydrazide (43038-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: NH₂NH₂*H₂O / methanol

With sulfuric acid; hydrazine hydrate; In methanol;

DOI:10.1016/S0968-0896(02)00469-8

Reference yield:

2-phenoxybenzoyl chloride (40501-36-8) → C26H20N2O4 + 2-phenoxybenzoic acid hydrazide (43038-37-5)

Guidance literature:

With hydrazine; In tetrahydrofuran; water; at -25 - 20 ℃; for 15.5h;

Reference yield:

methyl 2-phenoxybenzoate (21905-56-6) → 2-phenoxybenzoic acid hydrazide (43038-37-5)

Guidance literature:

With hydrazine hydrate; In methanol;

DOI:10.1016/S0968-0896(02)00469-8

upstream raw materials:

ethyl 2-phenoxybenzoate

methyl 2-phenoxybenzoate

2-phenoxybenzoic acid

2-phenoxybenzoyl chloride

Downstream raw materials:

5-(2-phenoxyphenyl)-[1,3,4]oxadiazole-2-thiol

5-(2-phenoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione

C₁₄H₁₀N₂O₂S

2-phenoxy-benzaldehyde-semicarbazone

Refernces

• 1、 De Azevedo, Ricardo Alexandre,Ferreira, Adilson Kleber,Jorge, Salomo Dria,Palace-Berl, Fanny,Pasqualoto, Kerly Fernanda Mesquita,Silva, Marcelo Nunes,Tavares, Leoberto Costa,Teixeira, Sarah Fernandes,Zingales, Bianca,Zorzi, Rodrigo Rocha. "Designing and exploring active N′-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients". . p. 330 - 339. Retrieved 2015/04/27.
• 2、 Kini, Suvarna G.,Bhat, Anilchandra R.,Bryant, Byron,Williamson, John S.,Dayan, Franck E.. "Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives". experimental part. p. 492 - 500. Retrieved 2009/08/07.