(3-Ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ylidene)propanedinitrile

Base Information

Chemical Name:(3-Ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ylidene)propanedinitrile
CAS No.:52927-74-9
Molecular Formula:C₂₀H₂₃N₃O₂
Molecular Weight:337.422
Hs Code.:
European Community (EC) Number:258-259-2
DSSTox Substance ID:DTXSID50967396
Mol file:52927-74-9.mol

Synonyms:52927-74-9;EINECS 258-259-2;(3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ylidene)propanedinitrile;DTXSID50967396;trans-(1)-(3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo(a)quinolizin-2-ylidene)malononitrile

Suppliers and Price of (3-Ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ylidene)propanedinitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (3-Ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ylidene)propanedinitrile

Chemical Property:

Vapor Pressure:2.49E-10mmHg at 25°C
Boiling Point:505.2°C at 760 mmHg
Flash Point:259.3°C
Density:1.2g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:337.17902698
Heavy Atom Count:25
Complexity:607

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1CN2CCC3=CC(=C(C=C3C2CC1=C(C#N)C#N)OC)OC

Technology Process of (3-Ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ylidene)propanedinitrile

There total 5 articles about (3-Ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ylidene)propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 47136-76-5
(3R^*,11bR^*)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo quinolizin-2-one

: 109-77-3
malononitrile

: 52927-74-9,111063-97-9
(+/-)-(3t-ethyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-ylidene)-malononitrile

Guidance literature:: With ammonium acetate; acetic acid; benzene;
DOI:10.1002/hlca.19590420319

Reference yield:

: 14028-68-3
ethyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

: 52927-74-9,111063-97-9
(+/-)-(3t-ethyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-ylidene)-malononitrile

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / Hydrieren des Reaktionsprodukts an Platin in Essigsaeure

2: sodium ethylate; toluene / Beim Erhitzen des Reaktionsprodukts mit wss. Salzsaeure

3: ammonium acetate; acetic acid; benzene

With ammonium acetate; sodium ethanolate; acetic acid; toluene; benzene;

Reference yield:

: 40129-54-2,112342-27-5
(6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetic acid ethyl ester

: 52927-74-9,111063-97-9
(+/-)-(3t-ethyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-ylidene)-malononitrile

Guidance literature:: Multi-step reaction with 4 steps

1: platinum; acetic acid / Hydrogenation

2: benzene / Hydrieren des Reaktionsprodukts an Platin in Essigsaeure

3: sodium ethylate; toluene / Beim Erhitzen des Reaktionsprodukts mit wss. Salzsaeure

4: ammonium acetate; acetic acid; benzene

With ammonium acetate; sodium ethanolate; acetic acid; toluene; platinum; benzene;