2-HYDROXYCYCLOHEXANONE DIMER

Base Information

• Chemical Name: 2-HYDROXYCYCLOHEXANONE DIMER
• CAS No.: 30282-14-5
• Molecular Formula: C₁₂H₂₀O₄
• Molecular Weight: 228.288
• Hs Code.: 29144090
• Mol file: 30282-14-5.mol

Synonyms:2-Hydroxycyclohexan-1-onedimer; 2-Hydroxycyclohexanone dimer; NSC 117392

Chemical Property of 2-HYDROXYCYCLOHEXANONE DIMER

Chemical Property:

• Vapor Pressure: 9.09E-08mmHg at 25°C
• Melting Point: 100-107oC(lit.)
• Boiling Point: 83-86 °C13 mm Hg(lit.)
• Flash Point: 175 °F
• PSA: 37.30000
• Density: 1.297g/cm³
• LogP: 0.49040
• Storage Temp.: Refrigerator (+4°C)
• Water Solubility.: Partly miscible in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxycyclohexanone dimer ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant involved in:? ;Synthesis of substrated for tin tetrachloride mediated fragmentation to produce ynones and ynoates1? ;Tandem oxidation coupling reactions with diamines2? ;Asymmetric allylic alkylation of enolates3? ;Formate reduction of allylic carbonates for polypropionate systems4 It is a reactant involved in the synthesis of substrates for tin tetrachloride mediated fragmentation to produce ynones and ynoates, tandem oxidation coupling reactions with diamines, asymmetric allylic alkylation of enolates and formate reduction of allylic carbonates for polypropionate systems. Reactant involved in:Synthesis of substrated for tin tetrachloride mediated fragmentation to produce ynones and ynoatesTandem oxidation coupling reactions with diaminesAsymmetric allylic alkylation of enolatesFormate reduction of allylic carbonates for polypropionate systems

Technology Process of 2-HYDROXYCYCLOHEXANONE DIMER

There total 7 articles about 2-HYDROXYCYCLOHEXANONE DIMER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-Chlorocyclohexanone (822-87-7) → 2-hydroxycyclohexanone dimer (60308-50-1,30282-14-5)

Guidance literature:

With sodium hydroxide; for 12h; Ambient temperature;

DOI:10.1016/S0957-4166(97)00456-4

Reference yield: 30.0%

1,2-Cyclohexanediol (931-17-9) → 2-hydroxycyclohexanone dimer (60308-50-1,30282-14-5)

Guidance literature:

With pyridine; N-hydroxyphthalimide; sodium perchlorate; In acetonitrile; electrolytical oxidation, anode potential 0.85 V;

DOI:10.1039/c39830000479

Reference yield:

cis-1,2-cyclohexane (1792-81-0) → 2-hydroxycyclohexanone dimer (60308-50-1,30282-14-5) + cyclohexanone-2-ol (533-60-8)

Guidance literature:

With [(neocuproine)Pd(OAc)]₂(OTf)₂; oxygen; In water; acetonitrile; at 25 ℃; for 8h; Reagent/catalyst; Overall yield = 81 %; Overall yield = 61 mg;

DOI:10.1021/ja4008694

upstream raw materials:

1,2-Cyclohexanediol

1,2-bis(trimethylsilyloxy)cyclohex-1-ene

2-Chlorocyclohexanone

cyclohexanone-2-ol

Downstream raw materials:

2,3,4,5,6,7-Hexahydro-1H-benzimidazol-2-on

N-(2-ethoxy-hexahydro-benzofuran-3a-yl)-O-methyl-hydroxylamine