2-(4-Methyl-1-piperazinyl)-4-propoxyquinazoline fumarate

Base Information

• Chemical Name: 2-(4-Methyl-1-piperazinyl)-4-propoxyquinazoline fumarate
• CAS No.: 129664-10-4
• Molecular Formula: C20H26N4O5
• Molecular Weight: 402.4442
• Mol file: 129664-10-4.mol

Synonyms:2-(4-Methyl-1-piperazinyl)-4-propoxyquinazoline fumarate;Quinazoline, 2-(4-methyl-1-piperazinyl)-4-propoxy-, (E)-2-butenedioate (1:1);129664-10-4;LS-140193

Chemical Property of 2-(4-Methyl-1-piperazinyl)-4-propoxyquinazoline fumarate

Chemical Property:

• Vapor Pressure: 1.91E-08mmHg at 25°C
• Boiling Point: 454.4°C at 760 mmHg
• Flash Point: 228.6°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 402.19031994
• Heavy Atom Count: 29
• Complexity: 438

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCOC1=NC(=NC2=CC=CC=C21)N3CCN(CC3)C.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CCCOC1=NC(=NC2=CC=CC=C21)N3CCN(CC3)C.C(=C/C(=O)O)\C(=O)O

Technology Process of 2-(4-Methyl-1-piperazinyl)-4-propoxyquinazoline fumarate

There total 2 articles about 2-(4-Methyl-1-piperazinyl)-4-propoxyquinazoline fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloro-2-(4-methyl-1-piperazinyl)quinazoline (39213-06-4) → 2-(4-Methyl-piperazin-1-yl)-4-propoxy-quinazoline; compound with (E)-but-2-enedioic acid (129664-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaH / dimethylformamide

2: ethanol

With sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.1286

Reference yield:

2-(4-Methyl-piperazin-1-yl)-4-propoxy-quinazoline (129663-62-3) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 2-(4-Methyl-piperazin-1-yl)-4-propoxy-quinazoline; compound with (E)-but-2-enedioic acid (129664-10-4)

Guidance literature:

In ethanol;

DOI:10.1248/cpb.38.1286

upstream raw materials:

2-(4-Methyl-piperazin-1-yl)-4-propoxy-quinazoline

(2E)-but-2-enedioic acid

4-Chloro-2-(4-methyl-1-piperazinyl)quinazoline