(E)-3,4-Dihydro-2-((1,1'-biphenyl)-4-ylmethylene)-1(2H)-naphthalenone

Base Information

• Chemical Name: (E)-3,4-Dihydro-2-((1,1'-biphenyl)-4-ylmethylene)-1(2H)-naphthalenone
• CAS No.: 132794-04-8
• Molecular Formula: C₂₃H₁₈O
• Molecular Weight: 310.395
• Nikkaji Number: J3.590.964H
• Wikidata: Q76145803
• Mol file: 132794-04-8.mol

Synonyms:(E)-3,4-Dihydro-2-((1,1'-biphenyl)-4-ylmethylene)-1(2H)-naphthalenone;132794-04-8;(2E)-2-[(4-phenylphenyl)methylidene]-3,4-dihydronaphthalen-1-one;1(2H)-Naphthalenone, 3,4-dihydro-2-((1,1'-biphenyl)-4-ylmethylene)-, (E)-;C23H18O;C23-H18-O;NCGC00324438-01;LS-95037;2-[(Biphenyl-4-yl)methylene]tetralin-1-one;J3.590.964H;AB01320172-02;Z46049295

Chemical Property of (E)-3,4-Dihydro-2-((1,1'-biphenyl)-4-ylmethylene)-1(2H)-naphthalenone

Chemical Property:

• Vapor Pressure: 2.1E-10mmHg at 25°C
• Boiling Point: 507.1°C at 760 mmHg
• Flash Point: 223.6°C
• Density: 1.167g/cm³
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 310.135765193
• Heavy Atom Count: 24
• Complexity: 462

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=CC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=CC=CC=C41
• Isomeric SMILES: C1C/C(=C\C2=CC=C(C=C2)C3=CC=CC=C3)/C(=O)C4=CC=CC=C41

Technology Process of (E)-3,4-Dihydro-2-((1,1'-biphenyl)-4-ylmethylene)-1(2H)-naphthalenone

There total 3 articles about (E)-3,4-Dihydro-2-((1,1'-biphenyl)-4-ylmethylene)-1(2H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4-bromo-benzaldehyde (1122-91-4) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) + phenylboronic acid (98-80-6) → (E)-2-([1,1'-biphenyl]-4-ylmethylene)-3,4-dihydronaphthalen-1(2H)-one (132794-04-8)

Guidance literature:

With potassium carbonate; In toluene; at 100 ℃; for 12h; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c6nj02402e

Reference yield:

4-Phenylbenzaldehyde (3218-36-8) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → (E)-2-([1,1'-biphenyl]-4-ylmethylene)-3,4-dihydronaphthalen-1(2H)-one (132794-04-8)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 0 - 20 ℃;

DOI:10.1021/acs.joc.1c02916

Reference yield:

2-methyl-1-tetralone (1590-08-5) + 4-bromo-benzaldehyde (1122-91-4) + phenylboronic acid (98-80-6) → (E)-2-([1,1'-biphenyl]-4-ylmethylene)-3,4-dihydronaphthalen-1(2H)-one (132794-04-8)

Guidance literature:

4-bromo-benzaldehyde; phenylboronic acid; With 1-octadecyl-5-oxopyrrolidine-3-carboxylic acid; palladium diacetate; potassium hydroxide; In water; at 80 ℃; for 1h;

2-methyl-1-tetralone; In water; at 80 ℃; for 5h;

DOI:10.1002/ejoc.201600095

upstream raw materials:

2-methyl-1-tetralone

4-bromo-benzaldehyde

phenylboronic acid

3,4-dihydronaphthalene-1(2H)-one