7-Bromo-5-chloroquinolin-8-ol

Base Information

• Chemical Name: 7-Bromo-5-chloroquinolin-8-ol
• CAS No.: 7640-33-7
• Molecular Formula: C9H5 Br Cl N O
• Molecular Weight: 258.502
• Hs Code.: 2933499090
• European Community (EC) Number: 231-574-2
• UNII: BC7DGV5BTR
• DSSTox Substance ID: DTXSID60227236
• Nikkaji Number: J48.378H
• Wikidata: Q83106919
• ChEMBL ID: CHEMBL139938
• Mol file: 7640-33-7.mol

Synonyms:7-Bromo-5-chloroquinolin-8-ol;7640-33-7;7-Bromo-5-chloro-8-hydroxyquinoline;8-Quinolinol, 7-bromo-5-chloro-;7-Bromo-5-chloro-8-quinolinol;C9H5BrClNO;5-Chloro-7-bromo-8-hydroxyquinoline;BRN 0153623;5-Chlor-7-brom-8-hydroxychinolin;BC7DGV5BTR;EINECS 231-574-2;5-Chlor-7-brom-8-hydroxychinolin [German];5-21-03-00289 (Beilstein Handbook Reference);UNII-BC7DGV5BTR;SCHEMBL360827;7-Brom-5-chlor-8-chinolinol;CHEMBL139938;ADJQQSUBKRASQN-UHFFFAOYSA-;DTXSID60227236;7-Bromo-5-chloro-quinolin-8-ol;7-Bromo-5-chloro-8-quinolinol #;MFCD00044601;AKOS015835345;CS-W010158;SB71625;AC-27862;LS-142484;B1190;FT-0636539;A838692

Chemical Property of 7-Bromo-5-chloroquinolin-8-ol

Chemical Property:

• Vapor Pressure: 1.23E-05mmHg at 25°C
• Melting Point: 181°C
• Boiling Point: 358.4ºC at 760 mmHg
• Flash Point: 170.6ºC
• PSA: 33.12000
• Density: 1.803g/cm3
• LogP: 3.35630
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 256.92430
• Heavy Atom Count: 13
• Complexity: 193

Purity/Quality:

98% ^*data from raw suppliers

7-Bromo-5-chloro-8-hydroxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-26-36/37/39-25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C(C=C2Cl)Br)O)N=C1

Technology Process of 7-Bromo-5-chloroquinolin-8-ol

There total 6 articles about 7-Bromo-5-chloroquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Chloro-8-hydroxyquinoline (130-16-5) → 7-bromo-5-chloroquinolin-8-ol (7640-33-7)

Guidance literature:

With bromine; at 20 ℃;

DOI:10.1007/s10895-018-2275-7

Reference yield:

broxyquinoline (521-74-4) → 7-bromo-5-chloroquinolin-8-ol (7640-33-7)

Guidance literature:

With n-butyllithium; hexachloroethane; sodium hydride; Yield given. Multistep reaction; 1.) THF, r.t., 2 h, 2.) THF, -78 deg C, 2 h;

DOI:10.1016/0040-4039(95)01776-E

Reference yield:

→ 7-bromo-5-chloroquinolin-8-ol (7640-33-7)

Guidance literature:

With tetrachloromethane; bromine;

upstream raw materials:

8-quinolinol

5-Chloro-8-hydroxyquinoline

broxyquinoline

2-hydroxy-5-chloro-aniline

Downstream raw materials:

C₁₀H₇BrClNO