methyl 2-(5-oxo-2H-furan-2-yl)acetate

Base Information

• Chemical Name: methyl 2-(5-oxo-2H-furan-2-yl)acetate
• CAS No.: 70441-90-6
• Molecular Formula: C7H8O4
• Molecular Weight: 0
• Mol file: 70441-90-6.mol

Synonyms:2,5-Dihydro-2-methyl-5-oxo-2-furanacetic acid;methyl 2-[(2R)-5-oxo-2H-furan-2-yl]acetate;(+/-)-4-Methylmuconolactone;2-Furanacetic acid,2,5-dihydro-2-methyl-5-oxo;

Chemical Property of methyl 2-(5-oxo-2H-furan-2-yl)acetate

Chemical Property:

• Vapor Pressure: 0.00235mmHg at 25°C
• Boiling Point: 288.4°C at 760 mmHg
• Flash Point: 149.9°C
• PSA: 52.60000
• Density: 1.228g/cm³
• LogP: 0.03110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-(5-oxo-2H-furan-2-yl)acetate

There total 4 articles about methyl 2-(5-oxo-2H-furan-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-5-carboxymethyl-2-furanone (6307-98-8) → (+/-)-4-Methylmuconolactone (70441-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / Br₂, NaHCO₃ / CH₂Cl₂; H₂O / 4 h / Ambient temperature

2: Bu₃SnH, AIBN / benzene / Ambient temperature

3: aq. NaOH / Ambient temperature

With sodium hydroxide; 2,2'-azobis(isobutyronitrile); bromine; tri-n-butyl-tin hydride; sodium hydrogencarbonate; In dichloromethane; water; benzene;

DOI:10.1039/p19960002111

Reference yield:

(+/-)-8-Bromo-1-methyl-2,6-dioxabicyclo[3.3.0]octane-3,7-dione → (+/-)-4-Methylmuconolactone (70441-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Bu₃SnH, AIBN / benzene / Ambient temperature

2: aq. NaOH / Ambient temperature

With sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene;

DOI:10.1039/p19960002111

Reference yield:

(+/-)-1-Methyl-2,6-dioxabicyclo[3.3.0]octane-3,7-dione → (+/-)-4-Methylmuconolactone (70441-90-6)

Guidance literature:

With sodium hydroxide; Ambient temperature;

DOI:10.1039/p19960002111

upstream raw materials:

4-methyl-5-carboxymethyl-2-furanone

Refernces