Dodecyldimethylphosphine oxide

Base Information

• Chemical Name: Dodecyldimethylphosphine oxide
• CAS No.: 871-95-4
• Molecular Formula: C14H31OP
• Molecular Weight: 246.373
• Hs Code.: 2901100000
• European Community (EC) Number: 212-818-7
• DSSTox Substance ID: DTXSID2073936
• Nikkaji Number: J195.149A
• Wikidata: Q82002503
• Mol file: 871-95-4.mol

Synonyms:dodecyldimethylphosphine oxide

Chemical Property of Dodecyldimethylphosphine oxide

Chemical Property:

• Vapor Pressure: 2.17E-05mmHg at 25°C
• Refractive Index: 1.433
• Boiling Point: 371.7 °C at 760 mmHg
• Flash Point: 178.6 °C
• PSA: 26.88000
• Density: 0.868 g/cm³
• LogP: 5.53000
• Storage Temp.: +15C to +30C
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 11
• Exact Mass: 246.211252606
• Heavy Atom Count: 16
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

APO-12 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCP(=O)(C)C
• Uses: APO-12 is a non-ionic detergent used in two-phase separation and purification of proteins.

Technology Process of Dodecyldimethylphosphine oxide

There total 6 articles about Dodecyldimethylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

dimethyl phosphine oxide (7211-39-4) + 1-dodecylbromide (143-15-7) → dodecyl(dimethyl)phosphine oxide (871-95-4)

Guidance literature:

dimethyl phosphine oxide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 22 ℃; for 0.25h; Inert atmosphere;

1-dodecylbromide; In tetrahydrofuran; at 22 ℃; for 16h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acs.organomet.7b00304

Reference yield:

1-dodecene (112-41-4,25067-08-7,62132-67-6) + dimethyl phosphine oxide (7211-39-4) → dodecyl(dimethyl)phosphine oxide (871-95-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile);

DOI:10.1021/jo01274a003

Reference yield:

dodecyl-dimethylphosphine (6794-87-2) → dodecyl(dimethyl)phosphine oxide (871-95-4)

Guidance literature:

With dihydrogen peroxide;

DOI:10.1021/jo01349a078

upstream raw materials:

n-dodecylphosphonic acid dichloride

trimethylaluminum

dodecyl-dimethylphosphine

1-dodecene

Refernces