4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide

Base Information

Chemical Name:4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide
CAS No.:77168-88-8
Molecular Formula:C₆H₆N₂O₄
Molecular Weight:170.125
Hs Code.:2933990090
Mol file:77168-88-8.mol

Synonyms:Pyrazinecarboxylicacid, 4,5-dihydro-6-methyl-5-oxo-, 1-oxide (9CI)

Suppliers and Price of 4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide

Chemical Property:

PSA：95.88000
Density:1.53g/cm³
LogP:0.22230

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide

There total 7 articles about 4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 77168-87-7
5-chloro-6-methyl-2-pyrazinecarboxylic acid 1-oxide

: 77168-88-8
4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide

Guidance literature:: With sodium hydroxide; for 2h; Heating;
DOI:10.1248/cpb.28.3057

Reference yield:

: 57005-61-5
1,6-dihydro-5-methyl-6-oxo-2,3-pyrazinedicarbonitrile

: 77168-88-8
4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / conc. HCl / 4 h / Heating

2: 75 percent / SOCl₂ / 2 h / Heating

3: 77 percent / POCl₃, DMF / 2 h / Heating

4: 9 percent / MCPBA / 1,2-dichloro-ethane / 39 h / 65 °C

5: 67 percent / K₂CO₃ / H₂O / 2 h / Ambient temperature

6: 30 percent / 1 N NaOH / 2 h / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In water; 1,2-dichloro-ethane;
DOI:10.1248/cpb.28.3057

Reference yield:

: 77168-82-2
4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxamide

: 77168-88-8
4,5-dihydro-6-methyl-5-oxo-2-pyrazinecarboxylic acid 1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 33 percent / 10percent NaOH / 3 h / Heating

2: 75 percent / SOCl₂ / 2 h / Heating

3: 77 percent / POCl₃, DMF / 2 h / Heating

4: 9 percent / MCPBA / 1,2-dichloro-ethane / 39 h / 65 °C

5: 67 percent / K₂CO₃ / H₂O / 2 h / Ambient temperature

6: 30 percent / 1 N NaOH / 2 h / Heating

With sodium hydroxide; thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In water; 1,2-dichloro-ethane;
DOI:10.1248/cpb.28.3057