4'-(dimethylamino)-17-hydroxy-17-(1-propynyl)benzo(12,12a)-11,18-cyclo-12a,12b-dihomo-estr-4-en-3-one

Base Information

Chemical Name:4'-(dimethylamino)-17-hydroxy-17-(1-propynyl)benzo(12,12a)-11,18-cyclo-12a,12b-dihomo-estr-4-en-3-one
CAS No.:156383-09-4
Molecular Formula:C₂₉H₃₅NO₂
Molecular Weight:429.602
Hs Code.:
Mol file:156383-09-4.mol

Synonyms:4’-(dimethylamino)-17-hydroxy-17-(1-propynyl)benzo(12,12a)-11,18-cyclo-12a,12b-dihomo-estr-4-en-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4'-(dimethylamino)-17-hydroxy-17-(1-propynyl)benzo(12,12a)-11,18-cyclo-12a,12b-dihomo-estr-4-en-3-one

Chemical Property:

Boiling Point:643.1°Cat760mmHg
Flash Point:342.7°C
PSA：40.54000
Density:1.22g/cm³
LogP:4.87850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4'-(dimethylamino)-17-hydroxy-17-(1-propynyl)benzo(12,12a)-11,18-cyclo-12a,12b-dihomo-estr-4-en-3-one

There total 6 articles about 4'-(dimethylamino)-17-hydroxy-17-(1-propynyl)benzo(12,12a)-11,18-cyclo-12a,12b-dihomo-estr-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 156383-14-1
4'-(dimethylamino)-3-ethoxy-17α-(1-propynyl)benzo<12,12a>-11α,18-cyclo-12a,12b-dihomo-13α-estra-3,5-dien-17β-ol

: 156383-09-4
4'-(dimethylamino)-17β-hydroxy-17α-(1-propynyl)benzo<12,12a>-11α,18-cyclo-12a,12b-dihomo-13α-estr-4-en-3-one

Guidance literature:: With hydrogenchloride; In acetone; for 1h;
DOI:10.1016/0039-128X(94)90026-4

Reference yield:

: 156383-12-9
4'-(dimethylamino)benzo<12,12a>-11α,18-cyclo-12a,12b-dihomo-13α-estr-4-ene-3,17-dione

: 156383-09-4
4'-(dimethylamino)-17β-hydroxy-17α-(1-propynyl)benzo<12,12a>-11α,18-cyclo-12a,12b-dihomo-13α-estr-4-en-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / p-TsOH, triethyl orthoformate / CH₂Cl₂

2: 1.) BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, 0 deg C, 2 h

3: 47 percent / 4 N aq. HCl / acetone / 1 h

With hydrogenchloride; n-butyllithium; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In dichloromethane; acetone;
DOI:10.1016/0039-128X(94)90026-4

Reference yield:

: 156383-13-0
4'-(dimethylamino)-3-ethoxybenzo<12,12a>-11α,18-cyclo-12a,12b-dihomo-13α-estra-3,5-dien-17-one

: 156383-09-4
4'-(dimethylamino)-17β-hydroxy-17α-(1-propynyl)benzo<12,12a>-11α,18-cyclo-12a,12b-dihomo-13α-estr-4-en-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, 0 deg C, 2 h

2: 47 percent / 4 N aq. HCl / acetone / 1 h

With hydrogenchloride; n-butyllithium; In acetone;
DOI:10.1016/0039-128X(94)90026-4