6,8-Difluoro-7-hydroxy-4-methylcoumarin

Base Information

Chemical Name:6,8-Difluoro-7-hydroxy-4-methylcoumarin
CAS No.:215868-23-8
Molecular Formula:C10H6F2O3
Molecular Weight:212.153
Hs Code.:
DSSTox Substance ID:DTXSID901318263
Nikkaji Number:J1.656.590C
Wikidata:Q27122705
Metabolomics Workbench ID:57829
ChEMBL ID:CHEMBL107323
Mol file:215868-23-8.mol

Synonyms:6,8-difluoro-4-methylumbelliferone;6,8-difluoro-4-methylumbelliferyl sulfate;DiFMUS

Suppliers and Price of 6,8-Difluoro-7-hydroxy-4-methylcoumarin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6,8-Difluoro-7-hydroxy-4-methylcoumarin(DIFMU)
2.5mg
$ 60.00

Biosynth Carbosynth
6,8-Difluoro-7-hydroxy-4-methylcoumarin
10 mg
$ 110.00

Biosynth Carbosynth
6,8-Difluoro-7-hydroxy-4-methylcoumarin
250 mg
$ 1000.00

Biosynth Carbosynth
6,8-Difluoro-7-hydroxy-4-methylcoumarin
100 mg
$ 500.00

Biosynth Carbosynth
6,8-Difluoro-7-hydroxy-4-methylcoumarin
50 mg
$ 350.00

Biosynth Carbosynth
6,8-Difluoro-7-hydroxy-4-methylcoumarin
25 mg
$ 225.00

Adipogen Life Sciences
6,8-Difluoro-7-hydroxy-4-methylcoumarin ≥98%(HPLC)
25 mg
$ 176.00

Total 3 raw suppliers

Chemical Property of 6,8-Difluoro-7-hydroxy-4-methylcoumarin

Chemical Property:

Melting Point:213-215°C
Boiling Point:332.3±42.0 °C(Predicted)
PKA:4.7, (at 22℃) (calcd.) 5.50 ± 0.20, most acidic, temperature: 25 °C
PSA：50.44000
Density:1.494±0.06 g/cm3(Predicted)
LogP:2.08520
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Insoluble in water; soluble in chloroform, N,N-dimethylformamide, dimethyl sulfoxide
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:212.02850037
Heavy Atom Count:15
Complexity:316

Purity/Quality:

98% ^*data from raw suppliers

6,8-Difluoro-7-hydroxy-4-methylcoumarin(DIFMU) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)OC2=C(C(=C(C=C12)F)O)F
Uses 6,8-Difluoro-7-hydroxy-4-methylcoumarin (DIFMU) was used for the diagnostic detection of natural killer cell-activity.

Technology Process of 6,8-Difluoro-7-hydroxy-4-methylcoumarin

There total 9 articles about 6,8-Difluoro-7-hydroxy-4-methylcoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 141-97-9
ethyl acetoacetate

: 195136-71-1
2,4-difluorobenzene-1,3-diol

: 215868-23-8
6,8-difluoro-7-hydroxy-4-methyl-2H-chromen-2-one

Guidance literature:: In methanesulfonic acid; at 0 - 20 ℃; for 28.33h;
DOI:10.1002/anie.201102965

Reference yield:

: 6,8-difluoro-4-methyl-2-oxo-2H-chromen-7-yl octanoate

: 124-07-2
Octanoic acid

: 215868-23-8
6,8-difluoro-7-hydroxy-4-methyl-2H-chromen-2-one

Guidance literature:: With PS-PIAT; Candida antarctica lipase B; In phosphate buffer; for 0.0166667h; pH=7.2; Enzyme kinetics;
DOI:10.1002/anie.200701125