Flusoxolol

Base Information

Chemical Name:Flusoxolol
CAS No.:84057-96-5
Molecular Formula:C22H30FNO4
Molecular Weight:391.483
Hs Code.:2922509090
UNII:1GPL60IRCI
DSSTox Substance ID:DTXSID70232952
Nikkaji Number:J33.096E
Wikipedia:Flusoxolol
Wikidata:Q76005802
NCI Thesaurus Code:C73018
ChEMBL ID:CHEMBL2114429
Mol file:84057-96-5.mol

Synonyms:(S)-1-(p-(2-((p-fluorophenethyl)oxy)ethoxy)phenoxy)-3- (isopropylamino)-2-propanol;1-(4-(2-(fluorophenethyloxy)ethyl)phenoxy)-3-isopropylamino-2-propanol HCl;flusoxolol;flusoxolol hydrochloride;Ro 31-1118;Ro 31-1411;RO-31-1118

Suppliers and Price of Flusoxolol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
FLUSOXOLOL 95.00%
5MG
$ 499.16

Total 5 raw suppliers

Chemical Property of Flusoxolol

Chemical Property:

Vapor Pressure:6.72E-12mmHg at 25°C
Boiling Point:526.2°C at 760 mmHg
Flash Point:272°C
PSA：59.95000
Density:1.125g/cm³
LogP:3.59240
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:13
Exact Mass:391.21588660
Heavy Atom Count:28
Complexity:383

Purity/Quality:

99% ^*data from raw suppliers

FLUSOXOLOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)NCC(COC1=CC=C(C=C1)OCCOCCC2=CC=C(C=C2)F)O
Isomeric SMILES:CC(C)NC[C@@H](COC1=CC=C(C=C1)OCCOCCC2=CC=C(C=C2)F)O

Technology Process of Flusoxolol

There total 4 articles about Flusoxolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7589-27-7
2-(4-Fluorophenyl)ethanol

: 84057-96-5,86941-24-4
flusoxolol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 60 deg C, 10 min, 2.) DMF, 60 deg C, 30 min

2: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: pyridine / 0.5 h

4: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00365a005

Reference yield:

: 81228-04-8
<<2-(4-fluorophenyl)ethyl>oxy>acetic acid

: 84057-96-5,86941-24-4
flusoxolol

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

2: pyridine / 0.5 h

3: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00365a005

Reference yield:

: 81228-11-7
4-Fluoro-1-[2-[2-hydroxyethoxy]ethyl]benzene

: 84057-96-5,86941-24-4
flusoxolol

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 0.5 h

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; sodium hydride;
DOI:10.1021/jm00365a005