1-Naphthaleneacetamide, 5,6,7,8-tetrahydro-N,N-dimethyl-

Base Information

• Chemical Name: 1-Naphthaleneacetamide, 5,6,7,8-tetrahydro-N,N-dimethyl-
• CAS No.: 3918-24-9
• Molecular Formula: C14H19NO
• Molecular Weight: 217.311
• DSSTox Substance ID: DTXSID60192410
• Wikidata: Q83065072
• Mol file: 3918-24-9.mol

Synonyms:BRN 2617287;alpha-Tetralylacetic acid dimethylamide;1-NAPHTHALENEACETAMIDE, 5,6,7,8-TETRAHYDRO-N,N-DIMETHYL-;N,N-Dimethyl-5,6,7,8-tetrahydro-1-naphthaleneacetamide;3918-24-9;DTXSID60192410;LS-94279

Chemical Property of 1-Naphthaleneacetamide, 5,6,7,8-tetrahydro-N,N-dimethyl-

Chemical Property:

• Vapor Pressure: 2.34E-05mmHg at 25°C
• Boiling Point: 359.7°C at 760 mmHg
• Flash Point: 162.8°C
• Density: 1.052g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 217.146664230
• Heavy Atom Count: 16
• Complexity: 249

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)CC1=CC=CC2=C1CCCC2

Technology Process of 1-Naphthaleneacetamide, 5,6,7,8-tetrahydro-N,N-dimethyl-

There total 2 articles about 1-Naphthaleneacetamide, 5,6,7,8-tetrahydro-N,N-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-dimethylamino-1-methoxyethylene (867-89-0) + 1,2,3,4-Tetrahydro-1-naphthol (529-33-9) → (5,6,7,8-tetrahydro-[1]naphthyl)-acetic acid dimethylamide (3918-24-9)

Guidance literature:

In tert-Amyl alcohol; Heating;

DOI:10.1002/hlca.19690520418

Reference yield:

→ (5,6,7,8-tetrahydro-[1]naphthyl)-acetic acid dimethylamide (3918-24-9)

Guidance literature:

/BRN= 46227/, Gemisch aus (CH3)2N-C(OCH3)2-CH3, (CH3)2N-C(OCH3)=CH2, tert.-Amylalkohol (120grad, 24h);

DOI:10.1002/hlca.19640470835

Reference yield:

(5,6,7,8-tetrahydro-[1]naphthyl)-acetic acid dimethylamide (3918-24-9) → (2-methyl-naphthalen-1-yl)-acetic acid (85-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Pd-C / 180 °C

2: (i) 3O>BF₄, CH₂Cl₂, (ii) aq. KOH, MeOH

3: SOCl₂

palladium on activated charcoal; In thionyl chloride;

DOI:10.1002/hlca.19690520418

upstream raw materials:

1-dimethylamino-1-methoxyethylene

1,2,3,4-Tetrahydro-1-naphthol

Downstream raw materials:

ethyl 2-(1-naphthyl)acetate

naphth-1-yl acetic acid

(2-methyl-naphthalen-1-yl)-acetic acid