N~2~-[(benzyloxy)carbonyl]-alpha-asparagine

Base Information

• Chemical Name: N~2~-[(benzyloxy)carbonyl]-alpha-asparagine
• CAS No.: 2799-12-4
• Molecular Formula: C12H14N2O5
• Molecular Weight: 266.25
• Mol file: 2799-12-4.mol

Synonyms:

Chemical Property of N~2~-[(benzyloxy)carbonyl]-alpha-asparagine

Chemical Property:

• Vapor Pressure: 2.05E-13mmHg at 25°C
• Boiling Point: 560.8°C at 760 mmHg
• Flash Point: 293°C
• Density: 1.355g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N~2~-[(benzyloxy)carbonyl]-alpha-asparagine

There total 13 articles about N~2~-[(benzyloxy)carbonyl]-alpha-asparagine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-Cbz-L-Asp (1152-61-0) → N-carbobenzoxy-L-aspartic acid amide (23632-73-7,2799-12-4)

Guidance literature:

With ammonium hydroxide; In water; for 5h; Ambient temperature;

DOI:10.1055/s-1991-26610

Reference yield:

C12H13NO6*(x)H3N → N-carbobenzoxy-L-aspartic acid amide (23632-73-7,2799-12-4)

Guidance literature:

With Bacillus licheniformis serine endoprotease; ammonia; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol; at 50 ℃; for 16h; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.tetlet.2012.05.039

Reference yield:

(S)-4-Carboxymethyl-oxazolidine-3-carboxylic acid benzyl ester → N-carbobenzoxy-L-aspartic acid amide (23632-73-7,2799-12-4)

Guidance literature:

With ammonia; In methanol; for 8h; Yield given; Ambient temperature;

DOI:10.1016/0960-894X(96)00220-X

upstream raw materials:

(S)-3-(benzyloxycarbonylamino)-4-ethoxy-4-oxobutanoic acid

N²-benzyloxycarbonyl-DL-isoasparagine

N-benzyloxycarbonyl-L-aspartic acid anhydride

N-Cbz-L-Asp

Downstream raw materials:

N-carbobenzoxy-L-aspartic acid amide

N²-benzyloxycarbonyl-D-isoasparagine

(S)-methyl 3-(benzyloxycarbonylamino)-3-cyanopropanoate

methyl (S)-4-amino-3-(((benzyloxy)carbonyl)amino)-4-oxobutanoate

Refernces

• 1、 Park,Lee,Choi. "Synthesis and anticonvulsant evaluation of a series of (R)- and (S)-N- Cbz-α-aminoglutarimide and succinimide". . p. 1297 - 1302. Retrieved 2007/10/03.