4-Hydroxy-2,3-trans-nonenal

Base Information

• Chemical Name: 4-Hydroxy-2,3-trans-nonenal
• CAS No.: 18286-49-2
• Molecular Formula: C9H16O2
• Molecular Weight: 156.2221
• Nikkaji Number: J740.950H
• Mol file: 18286-49-2.mol

Synonyms:4-Hydroxy-2,3-trans-nonenal;2-NONENAL, 4-HYDROXY-, (E)-;18286-49-2;(Z)-4-hydroxynon-2-enal;4-hydroxy-z-nonenal;(Z)-4-Hydroxy-2-nonenal;4-hydroxy-2-nonenal, (E)-isomer;HNE;LS-96933

Chemical Property of 4-Hydroxy-2,3-trans-nonenal

Chemical Property:

• Vapor Pressure: 0.000633mmHg at 25°C
• Boiling Point: 275.6°C at 760 mmHg
• Flash Point: 115.2°C
• Density: 0.941g/cm³
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 156.115029749
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCC(C=CC=O)O
• Isomeric SMILES: CCCCCC(/C=C\C=O)O

Technology Process of 4-Hydroxy-2,3-trans-nonenal

There total 68 articles about 4-Hydroxy-2,3-trans-nonenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-hydroxy-trans-2-nonenal-dimethylacetal (109296-10-8) → (E)-4-Hydroxy-2-nonenal (75899-68-2,18286-49-2,29343-52-0)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; water; for 1h; Ambient temperature;

Reference yield: 97.0%

C27H29O6(1-)*K(1+) → 1-hydroxy-2-propyl-9,10-anthraquinone-4-carboxylic acid (1086461-21-3) + (E)-4-Hydroxy-2-nonenal (75899-68-2,18286-49-2,29343-52-0)

Guidance literature:

C₂₇H₂₉O₆^(1-)*K⁽¹⁺⁾; In water; for 2.5h; pH=9; aq. buffer; Irradiation;

With hydrogenchloride; In water;

DOI:10.1039/b810954k

Reference yield: 94.0%

(±)-anti-4-(2-hydroxyethyl)-5-pentyl-1,3-dioxolan-2-one → (E)-4-Hydroxy-2-nonenal (75899-68-2,18286-49-2,29343-52-0)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 3h; Reagent/catalyst; Solvent; stereoselective reaction; Inert atmosphere; Reflux;

DOI:10.1002/asia.201900421

upstream raw materials:

Methyl linoleate

4-hydroxy-2-nonenal dimethyl acetal

1,1',2,2'-tetralinoleoyl cardiolipin

1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine

Downstream raw materials:

N-acetyl-S-(tetrahydro-5-hydroxy-2-pentyl-3-furanyl)-L-cysteine

2,3-epoxy-4-hydroxynonanal

4-hydroxynonanoic acid

(11Z)-retinal