2,4,6-Heptatrienamide,7-(3-aminophenyl)-N-(2-hydroxy-5-oxo-1-cyclopenten-1-yl)-, (2E,4E,6E)-

Base Information

Chemical Name:2,4,6-Heptatrienamide,7-(3-aminophenyl)-N-(2-hydroxy-5-oxo-1-cyclopenten-1-yl)-, (2E,4E,6E)-
CAS No.:126146-36-9
Molecular Formula:C18H18 N2 O3
Molecular Weight:310.353
Hs Code.:

Synonyms:2,4,6-Heptatrienamide,7-(3-aminophenyl)-N-(2-hydroxy-5-oxo-1-cyclopenten-1-yl)-, (E,E,E)-; Asuka mABA

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4,6-Heptatrienamide,7-(3-aminophenyl)-N-(2-hydroxy-5-oxo-1-cyclopenten-1-yl)-, (2E,4E,6E)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,4,6-Heptatrienamide,7-(3-aminophenyl)-N-(2-hydroxy-5-oxo-1-cyclopenten-1-yl)-, (2E,4E,6E)-

There total 11 articles about 2,4,6-Heptatrienamide,7-(3-aminophenyl)-N-(2-hydroxy-5-oxo-1-cyclopenten-1-yl)-, (2E,4E,6E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: {3-[(1E,3E,5E)-6-(2-Hydroxy-5-oxo-cyclopent-1-enylcarbamoyl)-hexa-1,3,5-trienyl]-phenyl}-carbamic acid tert-butyl ester

: 126146-36-9
N-(1-hydroxy-5-oxocyclopent-1-enyl)-7-(3-aminophenyl)hepta-2,4,6-trienamide

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00536-5

Reference yield: 55.0%

: 116655-90-4
N-(2-hydroxy-5-oxocyclopent-1-enyl)-7-<3-(2,4,6-trimethyldeca-2,4-dienoylamino)phenyl>hepta-2,4,6-trienamide

: 112406-54-9
(2E,4E,6R)-2,4,6-trimethyldeca-2,4-dienoic acid

: 126146-36-9
N-(1-hydroxy-5-oxocyclopent-1-enyl)-7-(3-aminophenyl)hepta-2,4,6-trienamide

Guidance literature:: With potassium hydroxide; In methanol; for 24h; Heating;

Reference yield:

: 168295-33-8
(2E,4E)-5-bromopenta-2,4-dienal

: 126146-36-9
N-(1-hydroxy-5-oxocyclopent-1-enyl)-7-(3-aminophenyl)hepta-2,4,6-trienamide

Guidance literature:: Multi-step reaction with 5 steps

1: 46 percent / aq. sodium chlorite, potassium dihydrogen orthophosphate, 2-methylbut-2-ene / 2-methyl-propan-2-ol / Ambient temperature

2: (COCl)2, DMF / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 4-dimethylaminopyridine, pyridine / CH₂Cl₂ / Ambient temperature

4: 70 percent / Dibal-H, PdCl₂(PPh₃)2 / dimethylformamide; tetrahydrofuran / 12 h / Ambient temperature

5: 62 percent / CF₃COOH, anisole / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; diisobutylaluminium hydride; methoxybenzene; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4020(98)00536-5