6-chloro-3(2H)-isoflavene

Base Information

• Chemical Name: 6-chloro-3(2H)-isoflavene
• CAS No.: 88040-01-1
• Molecular Formula: C15H11 Cl O
• Molecular Weight: 242.705
• Hs Code.: 2903999090
• Mol file: 88040-01-1.mol

Synonyms:6-chloro-3(2H)-isoflavene

Chemical Property of 6-chloro-3(2H)-isoflavene

Chemical Property:

• PSA: 9.23000
• LogP: 4.27300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-3(2H)-isoflavene

There total 9 articles about 6-chloro-3(2H)-isoflavene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-Chloro-3-phenyl-chromenylium; perchlorate → 6-Chloro-3-phenyl-4H-chromene + 6-chloro-3-phenyl-2H-benzopyran (88040-01-1)

Guidance literature:

With potassium borohydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)88245-3

Reference yield: 90.0%

[5-Chloro-2-(2-oxo-2-phenyl-ethoxy)-benzyl]-triphenyl-phosphonium; bromide (109790-42-3) → 6-chloro-3-phenyl-2H-benzopyran (88040-01-1)

Guidance literature:

With sodium; In ethanol; for 12h; Ambient temperature;

DOI:10.1016/0223-5234(87)90005-5

Reference yield: 70.0%

1-((E)-3-Bromo-2-phenyl-allyloxy)-4-chloro-benzene (112635-49-1,112635-50-4) → 6-chloro-3-phenyl-2H-benzopyran (88040-01-1)

Guidance literature:

In various solvent(s); for 2h; Heating;

upstream raw materials:

1-((E)-3-Bromo-2-phenyl-allyloxy)-4-chloro-benzene

[5-Chloro-2-(2-oxo-2-phenyl-ethoxy)-benzyl]-triphenyl-phosphonium; bromide

4-chloro-2-hydroxymethylphenol

2-(4-Chloro-2-hydroxymethyl-phenoxy)-1-phenyl-ethanone

Downstream raw materials:

(+/-)6-chloroisoflavan

Refernces

• 1、 Xia, Jingzhao,Nie, Yu,Yang, Guoqiang,Liu, Yangang,Zhang, Wanbin. "Iridium-Catalyzed Asymmetric Hydrogenation of 2H-Chromenes: A Highly Enantioselective Approach to Isoflavan Derivatives". supporting information. p. 4884 - 4887. Retrieved 2017/09/23.
• 2、 Burali, Carla,Desideri, Nicoletta,Stein, M. Luisa,Conti, Cinzia,Orsi, Nicola. "SYNTHESIS AND ANTI-RHINOVIRUS ACTIVITY OF HALOGEN-SUBSTITUTED ISOFLAVENES AND ISOFLAVANS". . p. 119 - 124. Retrieved 2007/10/02.