Alexine

Base Information

Chemical Name:Alexine
CAS No.:116174-63-1
Molecular Formula:C₈H₁₅NO₄
Molecular Weight:189.211
Hs Code.:
DSSTox Substance ID:DTXSID20151306
Nikkaji Number:J265.073H
Wikidata:Q27105723
Metabolomics Workbench ID:68376
Mol file:116174-63-1.mol

Synonyms:1-epialexine hemihydrate;3-(hydroxymethyl)-1,2,7-trihydroxypyrrolizidine;7-epialexine;alexine;australine

Suppliers and Price of Alexine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Alexine

Chemical Property:

Vapor Pressure:1.03E-08mmHg at 25°C
Boiling Point:417.4°C at 760 mmHg
Flash Point:263.5°C
PSA：84.16000
Density:1.53g/cm³
LogP:-2.54420
XLogP3:-1.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:189.10010796
Heavy Atom Count:13
Complexity:201

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(C(C(C2C1O)O)O)CO
Isomeric SMILES:C1CN2[C@@H]([C@H]([C@@H]([C@@H]2[C@H]1O)O)O)CO
General Description (+)-Alexine is a polyhydroxylated pyrrolizidine alkaloid that has been synthesized enantioselectively through methods involving anti-3-alkenyl-2-amido-3-hydroxy esters and stereoselective allylation strategies. Its synthesis highlights its structural complexity, featuring a pyrrolizidine core with multiple hydroxyl groups, and demonstrates its significance as a target in asymmetric synthesis.

Technology Process of Alexine

There total 45 articles about Alexine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (1R,2R,3R,7S,7aS)-2-(tert-butyldimethylsilyloxy)-3-[(tert-butyldimethylsilyloxy)methyl]-1,7-bis(methoxymethoxy)hexahydro-1H-pyrrolizine

: 116174-63-1
alexine

Guidance literature:: (1R,2R,3R,7S,7aS)-2-(tert-butyldimethylsilyloxy)-3-[(tert-butyldimethylsilyloxy)methyl]-1,7-bis(methoxymethoxy)hexahydro-1H-pyrrolizine; With hydrogenchloride; In methanol; water; at 40 ℃; for 3h;

With ammonium hydroxide; In water;
DOI:10.1055/s-0037-1611566