3-Hydroxylanost-7-en-32-oic acid

Base Information

• Chemical Name: 3-Hydroxylanost-7-en-32-oic acid
• CAS No.: 133621-76-8
• Molecular Formula: C₃₀H₅₀O₃
• Molecular Weight: 458.725
• DSSTox Substance ID: DTXSID20928212
• Nikkaji Number: J356.005H
• Wikidata: Q82902964
• Mol file: 133621-76-8.mol

Synonyms:3 beta-hydroxylanost-7-ene-32-oic acid;3-HLEOA;3-hydroxylanost-7-en-32-oic acid

Chemical Property of 3-Hydroxylanost-7-en-32-oic acid

Chemical Property:

• Vapor Pressure: 1.09E-14mmHg at 25°C
• Boiling Point: 556.3°Cat760mmHg
• Flash Point: 304.3°C
• PSA: 57.53000
• Density: 1.05g/cm³
• LogP: 7.47960
• XLogP3: 8.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 458.37599545
• Heavy Atom Count: 33
• Complexity: 796

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CCCC(C)C1CCC2(C1(CCC3C2=CCC4C3(CCC(C4(C)C)O)C)C)C(=O)O
• Isomeric SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@H]3C2=CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C(=O)O

Technology Process of 3-Hydroxylanost-7-en-32-oic acid

There total 8 articles about 3-Hydroxylanost-7-en-32-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-acetoxylanostan-7α-ol (4489-02-5) → 3β-Hydroxylanost-7-en-32-oic acid (133621-76-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 300 percent / lead tetraacetate, calcium carbonate, iodine / benzene / Irradiation

2: 0.28 g / Jones' reagent / acetone / 2 h / Ambient temperature

3: 0.1 g / 2 percent ethanolic NaOEt / ethanol / 168 h / Heating

4: diethyl ether

5: pyridine / 2 h / Ambient temperature

6: POCl₃, pyridine / 1 h / Heating

7: 10 percent methanolic KOH / 1 h / Heating

8: 40 mg / lithium iodide, 2,4,6-collidine / 3 h / Heating

With pyridine; 2,4,6-trimethyl-pyridine; lead(IV) acetate; potassium hydroxide; jones' reagent; iodine; sodium ethanolate; calcium carbonate; lithium iodide; trichlorophosphate; In diethyl ether; ethanol; acetone; benzene;

DOI:10.1248/cpb.39.100

Reference yield:

3β,7α-Dihydroxylanostan-32-oic acid (133621-72-4) → 3β-Hydroxylanost-7-en-32-oic acid (133621-76-8)

Guidance literature:

Multi-step reaction with 5 steps

1: diethyl ether

2: pyridine / 2 h / Ambient temperature

3: POCl₃, pyridine / 1 h / Heating

4: 10 percent methanolic KOH / 1 h / Heating

5: 40 mg / lithium iodide, 2,4,6-collidine / 3 h / Heating

With pyridine; 2,4,6-trimethyl-pyridine; potassium hydroxide; lithium iodide; trichlorophosphate; In diethyl ether;

DOI:10.1248/cpb.39.100

Reference yield:

7α,32-Epoxylanostane-3β,32-diol 3-acetate (133621-69-9) → 3β-Hydroxylanost-7-en-32-oic acid (133621-76-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 0.28 g / Jones' reagent / acetone / 2 h / Ambient temperature

2: 0.1 g / 2 percent ethanolic NaOEt / ethanol / 168 h / Heating

3: diethyl ether

4: pyridine / 2 h / Ambient temperature

5: POCl₃, pyridine / 1 h / Heating

6: 10 percent methanolic KOH / 1 h / Heating

7: 40 mg / lithium iodide, 2,4,6-collidine / 3 h / Heating

With pyridine; 2,4,6-trimethyl-pyridine; potassium hydroxide; jones' reagent; sodium ethanolate; lithium iodide; trichlorophosphate; In diethyl ether; ethanol; acetone;

DOI:10.1248/cpb.39.100

upstream raw materials:

Methyl 3β-hydroxylanost-7-en-32-oate

3β-acetoxylanostan-7α-ol

3β,7α-Dihydroxylanostan-32-oic acid

Methyl 3β,7α-dihydroxylanostan-32-oate

Refernces