N-(Phosphonoacetyl)-L-ornithine

Base Information

Chemical Name:N-(Phosphonoacetyl)-L-ornithine
CAS No.:63446-55-9
Molecular Formula:C7H15N2O6P
Molecular Weight:254.18
Hs Code.:2931900090
DSSTox Substance ID:DTXSID10979657
Nikkaji Number:J824.126K
Wikidata:Q27093102
Pharos Ligand ID:D6AXRW1BKJ9Y
Metabolomics Workbench ID:146624
ChEMBL ID:CHEMBL1160567

Synonyms:N(delta)-(phosphonoacetyl)-L-ornithine;N-(phosphonoacetyl)-L-ornithine;N-delta-(phosphonoacetyl)-L-ornithine;N-delta-PHOOR;N5-(phosphonoacetyl)-L-ornithine;N5-phosphonoacetyl-L-ornithine;PALO cpd

Suppliers and Price of N-(Phosphonoacetyl)-L-ornithine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of N-(Phosphonoacetyl)-L-ornithine

Chemical Property:

PSA：163.25000
Density:1.514g/cm³
LogP:0.01300
XLogP3:-5.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:254.06677320
Heavy Atom Count:16
Complexity:301

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(CC(C(=O)O)N)CNC(=O)CP(=O)(O)O
Isomeric SMILES:C(C[C@@H](C(=O)O)N)CNC(=O)CP(=O)(O)O

Technology Process of N-(Phosphonoacetyl)-L-ornithine

There total 3 articles about N-(Phosphonoacetyl)-L-ornithine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 92455-58-8
N^α-(Benzyloxycarbonyl)-N^δ-(dibenzylphosphonoacetyl)-L-ornithine benzyl ester

: 63446-55-9
N^δ-(Phosphonoacetyl)-L-orinithine

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; Ambient temperature;
DOI:10.1055/s-1984-30852

Reference yield:

: 7733-29-1,199924-46-4
Z-Orn(Boc)-OH

: 63446-55-9
N^δ-(Phosphonoacetyl)-L-orinithine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / triethylamine / ethyl acetate / 8 h / Heating

2: 61 percent / 1.) HCl, 2.) N-methylmorpholine, hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) dioxan, room temp., 1h, 2.) CH₂Cl₂, 0 deg C, 2h then room temp., 10h

3: 97 percent / H₂ / 10percent Pd/C / acetic acid / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In acetic acid; ethyl acetate;
DOI:10.1055/s-1984-30852

Reference yield:

: 92455-57-7
N^α-(Benzyloxycarbonyl)-N^δ-(t-butoxycarbonyl)-L-ornithine benzyl ester

: 63446-55-9
N^δ-(Phosphonoacetyl)-L-orinithine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / 1.) HCl, 2.) N-methylmorpholine, hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) dioxan, room temp., 1h, 2.) CH₂Cl₂, 0 deg C, 2h then room temp., 10h

2: 97 percent / H₂ / 10percent Pd/C / acetic acid / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In acetic acid;
DOI:10.1055/s-1984-30852