Synonyms:3,4,5,6-Tetrafluorpyridazin;Pyridazine,tetrafluoro;Tetrafluorpyrazin;Tetrafluor-pyridazin;Tetrafluorpyrydazin;tetrafluoro-pyridazine;perfluoropyridazine;
97% *data from raw suppliers
TETRAFLUOROPYRIDAZINE 95% *data from reagent suppliers
The research explores the synthesis of a tricyclic 9,10-dioxa-1,2-diaza-anthracene system from tetrafluoropyridazine and catechol through a sequential nucleophilic aromatic substitution ring annelation process. The purpose of this study is to further utilize perfluoroheteroaromatic derivatives for the creation of unusual polyfunctional heterocyclic architectures, which could be valuable in drug discovery programs. The researchers successfully synthesized the tricyclic scaffold and reacted it with various nucleophiles, including amines and sodium ethoxide, to produce a series of functional 9,10-dioxa-1,2-diaza-anthracene systems. The study concludes that a small range of dioxa-1,2-diaza-anthracene analogues can be efficiently synthesized from tetrafluoropyridazine in two steps, expanding the application of highly fluorinated heterocycles for the synthesis of rare heterocyclic architectures.
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