alpha-(Fluoromethyl)dehydroornithine

Base Information

Chemical Name:alpha-(Fluoromethyl)dehydroornithine
CAS No.:82006-84-6
Molecular Formula:C₆H₁₁FN₂O₂
Molecular Weight:162.164
Hs Code.:
ChEMBL ID:CHEMBL37859

Synonyms:alpha-(fluoromethyl)dehydroornithine;alpha-(fluoromethyl)dehydroornithine hydrochloride, (E)-isomer;alpha-FMDO;MDL 72246

Suppliers and Price of alpha-(Fluoromethyl)dehydroornithine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of alpha-(Fluoromethyl)dehydroornithine

Chemical Property:

Vapor Pressure:2.02E-06mmHg at 25°C
Boiling Point:367.9 °C at 760 mmHg
Flash Point:176.3 °C
Density:1.26 g/cm³
XLogP3:-3.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:162.08045576
Heavy Atom Count:11
Complexity:172

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(C=CC(CF)(C(=O)O)N)N
Isomeric SMILES:C(/C=C/C(CF)(C(=O)O)N)N

Technology Process of alpha-(Fluoromethyl)dehydroornithine

There total 4 articles about alpha-(Fluoromethyl)dehydroornithine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 151028-35-2
(E)-2-tert-Butoxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-fluoromethyl-pent-3-enoic acid methyl ester

: 112295-65-5,82006-84-6,97501-13-8,112295-66-6
(E)-dehydro-α-(monofluoromethyl) ornithine

Guidance literature:: With hydrogenchloride; methyloxirane; 1) reflux, 24 h, 2) i-PrOH;
DOI:10.1016/S0040-4039(00)74090-1

Reference yield:

: 151028-34-1
(E)-5-Bromo-2-tert-butoxycarbonylamino-2-fluoromethyl-pent-3-enoic acid methyl ester

: 112295-65-5,82006-84-6,97501-13-8,112295-66-6
(E)-dehydro-α-(monofluoromethyl) ornithine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / dimethylformamide / 80 °C

2: 82 percent / 1) aq. HCl, 2) propylene oxide / 1) reflux, 24 h, 2) i-PrOH

With hydrogenchloride; methyloxirane; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74090-1

Reference yield:

: 151028-33-0
2-tert-Butoxycarbonylamino-2-fluoromethyl-3-hydroxy-pent-4-enoic acid methyl ester

: 112295-65-5,82006-84-6,97501-13-8,112295-66-6
(E)-dehydro-α-(monofluoromethyl) ornithine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / tetramethyl-α-bromoenamine / CH2Cl2

2: 84 percent / dimethylformamide / 80 °C

3: 82 percent / 1) aq. HCl, 2) propylene oxide / 1) reflux, 24 h, 2) i-PrOH

With hydrogenchloride; tetramethyl-α-bromoenamine; methyloxirane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74090-1