6-Cyano-7-nitroquinoxaline-2,3-dione

Base Information

• Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione
• CAS No.: 115066-14-3
• Molecular Formula: C9H4N4O4
• Molecular Weight: 232.1525
• Hs Code.: 29335990
• European Community (EC) Number: 878-456-2
• UNII: 6OTE87SCCW
• DSSTox Substance ID: DTXSID40893918
• Nikkaji Number: J126.315C
• Wikipedia: CNQX
• Wikidata: Q4386534,Q27458884
• Metabolomics Workbench ID: 70081
• ChEMBL ID: CHEMBL222418
• Mol file: 115066-14-3.mol

Synonyms:1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;6 Cyano 2,3 dihydroxy 7 nitroquinoxaline;6 Cyano 7 nitroquinoxaline 2,3 dione;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX;FG 9065;FG-9065;FG9065

Chemical Property of 6-Cyano-7-nitroquinoxaline-2,3-dione

Chemical Property:

• Appearance/Colour: pale yellow solid
• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 300 °C
• Refractive Index: 1.803
• Boiling Point: 659.3 °C at 760 mmHg
• PKA: 8.16±0.20(Predicted)
• Flash Point: 352.6 °C
• PSA: 135.33000
• Density: 1.71 g/cm³
• LogP: 0.51948
• Storage Temp.: Desiccate at RT
• Solubility.: H2O: 10 mg/mL
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 232.02325462
• Heavy Atom Count: 17
• Complexity: 434

Purity/Quality:

≥98% ^*data from raw suppliers

CNQX disodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
• Uses: CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. CNQX disodium salt hydrate has been used as:as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112) A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively

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