N-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine

Base Information

• Chemical Name: N-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine
• CAS No.: 24997-85-1
• Molecular Formula: C19H25 N O4
• Molecular Weight: 331.412
• Mol file: 24997-85-1.mol

Synonyms:Veratrylamine,N-(3,4-dimethoxyphenethyl)- (7CI,8CI); N-(3,4-Dimethoxyphenethyl)veratrylamine;Ryllistine

Chemical Property of N-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine

Chemical Property:

• PSA: 48.95000
• LogP: 3.44420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine

There total 11 articles about N-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-<2-(3,4-dimethoxybenzyl)ethyl>-3,4-dimethoxybenzaldimine (18034-37-2) → N-<2-(3,4-dimethoxybenzyl)(3,4-dimethoxyphenyl)>ethanamine (24997-85-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 12h; under 2068.6 Torr;

DOI:10.1016/S0040-4020(01)88259-4

Reference yield:

(E)-N-(3,4-dimethoxyphenethyl)-1-(3,4-dimethoxyphenyl)methanimine → N-<2-(3,4-dimethoxybenzyl)(3,4-dimethoxyphenyl)>ethanamine (24997-85-1)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; silica gel; In methanol; at 60 ℃; for 0.0833333h; under 15001.5 Torr;

DOI:10.1021/acs.joc.1c00602

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → N-<2-(3,4-dimethoxybenzyl)(3,4-dimethoxyphenyl)>ethanamine (24997-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: NaBH₄ / methanol / 0 - 5 °C

With sodium tetrahydroborate; In methanol; benzene;

DOI:10.1007/BF00630535

upstream raw materials:

N-<2-(3,4-dimethoxybenzyl)ethyl>-3,4-dimethoxybenzaldimine

3,4-dimethoxy-benzaldehyde

2-(3,4-dimethoxyphenyl)-ethylamine

1,2-dimethoxy-4-(2-nitroethyl)benzene

Downstream raw materials:

1,2,3,4-tetrahydro-6,7-dimethoxy-2-(3,4-dimethoxybenzyl)isoquinoline

N-(3,4-dimethoxybenzyl)-N'-methyl-2-(3,4-dimethoxyphenyl)ethanamine

4,4'-(2-aza-butanediyl)-di-pyrocatechol

N-(3,4-dimethoxybenzyl)-N'-formyl-2-(3,4-dimethoxyphenyl)ethanamine